Detailed information of TA system TA240099

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 2033439..2033909
• Replicon: chromosome
• Accession: NZ_CP094731
• Organism: Staphylococcus epidermidis strain IVB6208

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: A0A939NNQ7
• Locus tag: MUA70_RS09675
• Protein ID: WP_002445998.1
• Coordinates: 2033721..2033909 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: A0A829M688
• Locus tag: MUA70_RS09670
• Protein ID: WP_002445999.1
• Coordinates: 2033439..2033696 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA70_RS09635 (MUA70_09595)	2028705..2029247	-	543	WP_002475966.1	nitroreductase	-
MUA70_RS09640 (MUA70_09600)	2029328..2030044	-	717	WP_002475962.1	type I 3-dehydroquinate dehydratase	-
MUA70_RS09645 (MUA70_09605)	2030205..2030627	+	423	WP_002457221.1	organic hydroperoxide resistance protein	-
MUA70_RS09650 (MUA70_09610)	2031033..2031533	+	501	WP_002446003.1	GNAT family N-acetyltransferase	-
MUA70_RS09655 (MUA70_09615)	2031804..2032391	-	588	WP_002490737.1	histidine phosphatase family protein	-
MUA70_RS09660 (MUA70_09620)	2032605..2032841	+	237	WP_262622649.1	hypothetical protein	-
MUA70_RS09665 (MUA70_09625)	2032833..2033036	-	204	WP_002446000.1	sterile alpha motif-like domain-containing protein	-
MUA70_RS09670 (MUA70_09630)	2033439..2033696	+	258	WP_002445999.1	hypothetical protein	Antitoxin
MUA70_RS09675 (MUA70_09635)	2033721..2033909	+	189	WP_002445998.1	hypothetical protein	Toxin
MUA70_RS09680 (MUA70_09640)	2034099..2034653	+	555	WP_002490730.1	lipoprotein N-acylation protein LnsA	-
MUA70_RS09685 (MUA70_09645)	2034711..2034944	-	234	WP_002445996.1	hypothetical protein	-
MUA70_RS09690 (MUA70_09650)	2035158..2035904	+	747	WP_070593324.1	poly-gamma-glutamate hydrolase family protein	-
MUA70_RS09695 (MUA70_09655)	2036003..2036287	+	285	WP_001829635.1	hypothetical protein	-
MUA70_RS09700 (MUA70_09660)	2036312..2036536	+	225	WP_002474944.1	hypothetical protein	-
MUA70_RS09705 (MUA70_09665)	2037155..2037355	-	201	WP_001829681.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (4-210)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (5-53)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7257.95 Da
• Isoelectric Point: 9.8369

>T240099 WP_002445998.1 NZ_CP094731:2033721-2033909 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKREERKESYLGFTVIFLIFGFAILIYTFIFGIL

Nucleotide

• Length: 189 bp

>T240099 NZ_LS483510:c1047054-1046320 [Mycoplasma mycoides subsp. capri]
CTGAAAAAAATATCTAAGAATAAGGATAAGATAAATATCATATTTAAAGGAGGTTTTTTGCTTTCTAATATAATTGGAAT
AAAAGAAAGAACAACCAAAGATATTGATTATTTATTAAATAACATTGTATTTTCACCTGATCGTATAAAAGAATTATTTG
AAGATATTTTAGATTATAAGAAAGGAGATAAAATACATTTTCAAATTCAAAAAATAAATGAAATTAAGAAAAAAGAAAAA
TATACAGGTTTTAGAATAACTGTAGAATGCAAATTAGATGAAATAGTAGAAATTATAAAAATAGATGTAGCAACAGGTGA
TATCATCACTTCCTGTCAAGTTAGATATAATATTGAAAATATTTTTCATAACAACAGTTTTTATGTTTATGGTTATAACT
TAGAAACTATGTTGGCTGAAAAAATTCATGCAATCAAAGAATTAAGCTTGTTTAATACTAGAACAAAAGATTTCTATGAT
ATATACCTAATTTATAATTTAAAAAGAGATGATATTGACTATATGACGTTGAAAAATGCTTGTATTAATACATTCAAACA
AAGAAACAGCATTTTTGATAAAGACGATTTATTAGAGTTACTCAATAAAATAAAAAATTCGCAATCTACTCATAATTTAT
GAACTAAACAAAAAAATATATATTTTTATAATAAAAACATAGATTTTAAATTTATCATTCAGTCAATTATTGAACTTATT
AAAAACATTAAATAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10014.05 Da
• Isoelectric Point: 4.5440

>AT240099 WP_002445999.1 NZ_CP094731:2033439-2033696 [Staphylococcus epidermidis]
MKLNKANVFNLIFTILFFTFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Nucleotide

• Length: 258 bp

>AT240099 NZ_LS483510:c1047753-1047154 [Mycoplasma mycoides subsp. capri]
ATGAACTATGTAGAAAAAATAAAAGAAAAAGCCATTCAAAATAATGGACTAATAACAAGAAAAGAAATTATAAGTCTAAA
AATCCCACCTATTTATATAACTAGAATGGTAAGAAAAAAAGAACTTGAAAAAATTGATATTGGAATTTATGCACTAACTT
CACTAGATAATTATCCTTACGATCCCGAATTTAATTTTTGTTCAAGATATCAAGTTCCTGTTTTTTCATATGTTTATGCA
TTAAACTTATTTGATTTTACTGATGTTATTCCACTTAATTTTGAAGTAACTGTTTATAAAGGGTATAATGCACATAATCT
TAAACCTAACACAATAGTTCACTATGTTAATAAAGAAATTTTTAATCTAGGAATTACTGAAATTAGAAATGCTTTTGGAA
ATTGGGTAAGAACCTATGATATTGAAAGAACAATTTGTGATCTTATTAAAAATAGAAAAAATATTAATGTTGAACTTTTT
GTAAAAACTATGAATAACTATGTTAATTATGAAAAAAAGGACTGGAATAAACTTTATGAATATGCTGAAAAAATGCACAT
TGAAAAAGAGCTAGTAGAAATATTTCAACTTATTATTTAA

Structures

Antitoxin

• AlphaFold DB: A0A829M688