Detailed information of TA system TA240098

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1034343..1035148
• Replicon: chromosome
• Accession: NZ_CP094731
• Organism: Staphylococcus epidermidis strain IVB6208

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: MUA70_RS05010
• Protein ID: WP_020361957.1
• Coordinates: 1034966..1035148 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A829M6U1
• Locus tag: MUA70_RS05005
• Protein ID: WP_020364054.1
• Coordinates: 1034343..1034942 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA70_RS04985 (MUA70_04960)	1030068..1031525	+	1458	WP_002457887.1	ABC transporter substrate-binding protein/permease	-
MUA70_RS04990 (MUA70_04965)	1031518..1032240	+	723	WP_002446766.1	amino acid ABC transporter ATP-binding protein	-
MUA70_RS04995 (MUA70_04970)	1032588..1033718	+	1131	WP_002476052.1	tRNA epoxyqueuosine(34) reductase QueG	-
MUA70_RS05000 (MUA70_04975)	1033715..1034185	+	471	WP_002446764.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MUA70_RS05005 (MUA70_04980)	1034343..1034942	+	600	WP_020364054.1	glucosamine-6-phosphate isomerase	Antitoxin
MUA70_RS05010 (MUA70_04985)	1034966..1035148	+	183	WP_020361957.1	SAS053 family protein	Toxin
MUA70_RS05015 (MUA70_04990)	1035300..1035704	+	405	WP_070846328.1	hypothetical protein	-
MUA70_RS05020 (MUA70_04995)	1035896..1037281	+	1386	WP_020361955.1	class II fumarate hydratase	-
MUA70_RS05025 (MUA70_05000)	1037756..1038238	+	483	Protein_956	transposase	-
MUA70_RS05030 (MUA70_05005)	1038412..1039236	-	825	WP_002457882.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1037927..1038238	311

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (125-195)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7053.64 Da
• Isoelectric Point: 4.3016

>T240098 WP_020361957.1 NZ_CP094731:1034966-1035148 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLSQPHDNEVRSDFKNSK

Nucleotide

• Length: 183 bp

>T240098 NZ_LS483509:c1052127-1051393 [Mycoplasma mycoides subsp. capri]
CTGAAAAAAATATCTAAGAATAAGGATAAGATAAATATCATATTTAAAGGAGGTTTTTTGCTTTCTAATATAATTGGAAT
AAAAGAAAGAACAACCAAAGATATTGATTATTTATTAAATAACATTGTATTTTCACCTGATCGTATAAAAGAATTATTTG
AAGATATTTTAGATTATAAGAAAGGAGATAAAATACATTTTCAAATTCAAAAAATAAATGAAATTAAGAAAAAAGAAAAA
TATACAGGTTTTAGAATAACTGTAGAATGCAAATTAGATGAAATAGTAGAAATTATAAAAATAGATGTAGCAACAGGTGA
TATCATCACTTCCTGTCAAGTTAGATATAATATTGAAAATATTTTTCATAACAACAGTTTTTATGTTTATGGTTATAACT
TAGAAACTATGTTGGCTGAAAAAATTCATGCAATCAAAGAATTAAGCTTGTTTAATACTAGAACAAAAGATTTCTATGAT
ATATACCTAATTTATAATTTAAAAAGAGATGATATTGACTATATGACGTTGAAAAATGCTTGTATTAATACATTCAAACA
AAGAAACAGCATTTTTGATAAAGACGATTTATTAGAGTTACTCAATAAAATAAAAAATTCGCAATCTACTCATAATTTAT
GAACTAAACAAAAAAATATATATTTTTATAATAAAAACATAGATTTTAAATTTATCATTCAGTCAATTATTGAACTTATT
AAAAACATTAAATAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22663.60 Da
• Isoelectric Point: 4.9942

>AT240098 WP_020364054.1 NZ_CP094731:1034343-1034942 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLGKEHAPVFDELKKNVENHAVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDVSVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAVGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT240098 NZ_LS483509:c1052826-1052227 [Mycoplasma mycoides subsp. capri]
ATGAACTATGTAGAAAAAATAAAAGAAAAAGCCATTCAAAATAATGGACTAATAACAAGAAAAGAAATTATAAGTCTAAA
AATCCCACCTATTTATATAACTAGAATGGTAAGAAAAAAAGAACTTGAAAAAATTGATATTGGAATTTATGCACTAACTT
CACTAGATAATTATCCTTACGATCCCGAATTTAATTTTTGTTCAAGATATCAAGTTCCTGTTTTTTCATATGTTTATGCA
TTAAACTTATTTGATTTTACTGATGTTATTCCACTTAATTTTGAAGTAACTGTTTATAAAGGGTATAATGCACATAATCT
TAAACCTAACACAATAGTTCACTATGTTAATAAAGAAATTTTTAATCTAGGAATTACTGAAATTAGAAATGCTTTTGGAA
ATTGGGTAAGAACCTATGATATTGAAAGAACAATTTGTGATCTTATTAAAAATAGAAAAAATATTAATGTTGAACTTTTT
GTAAAAACTATGAATAACTATGTTAATTATGAAAAAAAGGACTGGAATAAACTTTATGAATATGCTGAAAAAATGCACAT
TGAAAAAGAGCTAGTAGAAATATTTCAACTTATTATTTAA

Structures

Antitoxin

• AlphaFold DB: A0A829M6U1