Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 887184..887713 Replicon chromosome
Accession NZ_CP094731
Organism Staphylococcus epidermidis strain IVB6208

Toxin (Protein)


Gene name mazF Uniprot ID A0A939SRT1
Locus tag MUA70_RS04190 Protein ID WP_002447757.1
Coordinates 887351..887713 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag MUA70_RS04185 Protein ID WP_001829931.1
Coordinates 887184..887354 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA70_RS04160 (MUA70_04135) 883009..883488 + 480 WP_002447762.1 PH domain-containing protein -
MUA70_RS04165 (MUA70_04140) 883481..884986 + 1506 WP_194373689.1 PH domain-containing protein -
MUA70_RS04170 (MUA70_04145) 884973..885491 + 519 WP_002447760.1 PH domain-containing protein -
MUA70_RS04175 (MUA70_04150) 885530..885883 + 354 WP_002447759.1 holo-ACP synthase -
MUA70_RS04180 (MUA70_04155) 885949..887097 + 1149 WP_002458690.1 alanine racemase -
MUA70_RS04185 (MUA70_04160) 887184..887354 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA70_RS04190 (MUA70_04165) 887351..887713 + 363 WP_002447757.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA70_RS04195 (MUA70_04170) 888058..889059 + 1002 WP_002447756.1 PP2C family protein-serine/threonine phosphatase -
MUA70_RS04200 (MUA70_04175) 889159..889485 + 327 WP_001829952.1 anti-sigma factor antagonist -
MUA70_RS04205 (MUA70_04180) 889487..889966 + 480 WP_002447755.1 anti-sigma B factor RsbW -
MUA70_RS04210 (MUA70_04185) 889941..890711 + 771 WP_002447754.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13483.62 Da        Isoelectric Point: 9.9522

>T240097 WP_002447757.1 NZ_CP094731:887351-887713 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSDSKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T240097 NZ_LS483508:c210750-209998 [Mycoplasma mycoides subsp. capri]
ATGATATCCATATTAGAAAAAATTGTTAAAAGTAAAAATAAGCAAAACTTTATAATTAAAGGCGGATTCTTACTTTCTAA
TATGATGAGTTTAAACGAAAGAACCACTCAAGATATAGATTGCCTAATAAAGGGTATCAATTTTGTTAAAGAGAATATTC
TAAAAATTATTTCTGATGTACTAAGATATGATTTTACTGACTTTATAGAATATGAAATAAAAGAAATAACAGAAATAAAA
AAGAGAGACAAATATAATGGATTTAGAGTCAAAATATTATGTAAATTAGAAAAGTTAGAAGAAATAGTAAAAATAGATTT
AGCAATTGGTGATGTTATAACACCATCTGAGATTAAATACAATTTTAAAAATATCTTTTCAAATAGTAGCTTTGAAATAC
AAGCATATAATTTAGAAACGATATTAGCTGAAAAAATATTTATAATTAATAATTTAAATATACAATCAACTAGAATAAAA
GATCTTTATGATATTTTTTTAATATATAGTTTGAAAGAGTTTGAGATTGATTATAATATTCTAAAATGTGCTTGTTTAAA
TACTTTTAAAAAAAGAAATACTGTTTTTAATATAGATTTAATACTTAATTTATTAAATGAAATTAACCAATTAGATATTT
TTAAATTACTTTGAAATAATTACAAGCAAAAATACTTTTACGCTCAAAAAATAGAATTTGAAATACTGGTGGAATCTGTA
ATTAAGCTTTTAGAAAAGTTAAAAAGCTCTTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT240097 WP_001829931.1 NZ_CP094731:887184-887354 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT240097 NZ_LS483508:c211433-210837 [Mycoplasma mycoides subsp. capri]
ATGAATTATAAAGAACAACTGATAAAAGAAGCCAAAAAAAGAGACGGTCTTATTACAAGAAAAGAAATTATAAATTTAAA
AATTCCATCAATTTATATTACAAGAATGATTAGAAGTAATGAATTAGAAAAAGTCGATATTGGTATTTATGCTCTAACTT
CTGAAAATTGGCACTATGATCCTGATTATAATTTTAGTATCAGACATAAAACACCTATTTTTTCTTATACTTATGCACTT
ACATTTTTTGATTTTACAGATGTTATTCCAATGTTTCGTGATGTAACTGTTTATCATGGATATAATGCTCATAATTTAGA
TCCACAAACTAGAGTACACTATGTTTCAAAAGATATATATGAACTTGGAGTTGTAGAAGTAAAAACAAATTGTGGTAATA
AAGTTAGAGCTTATAATATTGAAAGAACAATTTGTGACTTTATTAAACATAGAGATAAAATCGAAGCTGAACTATTTGCA
AAAACTATGTATAAATATTCTGAATATGAAAAAAGAGATTGAAAAAAACTTCATGAATATGCTAAAAAAATGAACATTGG
TAAGAAAGTTTATGAAGTTTTTCAAGTATTAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References