Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 876000..876509 Replicon chromosome
Accession NZ_CP094731
Organism Staphylococcus epidermidis strain IVB6208

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0E1VPY9
Locus tag MUA70_RS04130 Protein ID WP_002447767.1
Coordinates 876300..876509 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A829M395
Locus tag MUA70_RS04125 Protein ID WP_002458700.1
Coordinates 876000..876293 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA70_RS04100 (MUA70_04075) 871007..871795 + 789 WP_002475462.1 hydroxyethylthiazole kinase -
MUA70_RS04105 (MUA70_04080) 871801..872439 + 639 WP_002458704.1 thiamine phosphate synthase -
MUA70_RS04110 (MUA70_04085) 872528..873400 + 873 WP_002458703.1 membrane protein insertase YidC -
MUA70_RS04115 (MUA70_04090) 873507..874160 - 654 WP_002475468.1 HD domain-containing protein -
MUA70_RS04120 (MUA70_04095) 874342..875826 - 1485 WP_002447769.1 cardiolipin synthase -
MUA70_RS04125 (MUA70_04100) 876000..876293 + 294 WP_002458700.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA70_RS04130 (MUA70_04105) 876300..876509 + 210 WP_002447767.1 cation transporter Toxin
MUA70_RS04135 (MUA70_04110) 876653..876790 + 138 WP_001829949.1 Lmo0850 family protein -
MUA70_RS04140 (MUA70_04115) 876889..878100 - 1212 WP_002447766.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA70_RS04145 (MUA70_04120) 878491..879564 + 1074 WP_070592793.1 D-alanine--D-alanine ligase -
MUA70_RS04150 (MUA70_04125) 879576..880931 + 1356 WP_070592794.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(10-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 8008.28 Da        Isoelectric Point: 6.4556

>T240096 WP_002447767.1 NZ_CP094731:876300-876509 [Staphylococcus epidermidis]
MKLKKGLIHVSGIKTTEQEKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDCGFRIL

Download         Length: 210 bp

>T240096 NZ_LS483507:c1048765-1048031 [Mycoplasma mycoides subsp. capri]
CTGAAAAAAATATCTAAGAATAAGGATAAGATAAATATCATATTTAAAGGAGGTTTTTTGCTTTCTAATATAATTGGAAT
AAAAGAAAGAACAACCAAAGATATTGATTATTTATTAAATAACATTGTATTTTCACCTGATCGTATAAAAGAATTATTTG
AAGATATTTTAGATTATAAGAAAGGAGATAAAATACATTTTCAAATTCAAAAAATAAATGAAATTAAGAAAAAAGAAAAA
TATACAGGTTTTAGAATAACTGTAGAATGCAAATTAGATGAAATAGTAGAAATTATAAAAATAGATGTAGCAACAGGTGA
TATCATCACTTCCTGTCAAGTTAGATATAATATTGAAAATATTTTTCATAACAACAGTTTTTATGTTTATGGTTATAACT
TAGAAACTATGTTGGCTGAAAAAATTCATGCAATCAAAGAATTAAGCTTGTTTAATACTAGAACAAAAGATTTCTATGAT
ATATACCTAATTTATAATTTAAAAAGAGATGATATTGACTATATGACGTTGAAAAATGCTTGTATTAATACATTCAAACA
AAGAAACAGCATTTTTGATAAAGACGATTTATTAGAGTTACTCAATAAAATAAAAAATTCGCAATCTACTCATAATTTAT
GAACTAAACAAAAAAATATATATTTTTATAATAAAAACATAGATTTTAAATTTATCATTCAGTCAATTATTGAACTTATT
AAAAACATTAAATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11082.71 Da        Isoelectric Point: 5.5778

>AT240096 WP_002458700.1 NZ_CP094731:876000-876293 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVAIKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT240096 NZ_LS483507:c1049464-1048865 [Mycoplasma mycoides subsp. capri]
ATGAACTATGTAGAAAAAATAAAAGAAAAAGCCATTCAAAATAATGGACTAATAACAAGAAAAGAAATTATAAGTCTAAA
AATCCCACCTATTTATATAACTAGAATGGTAAGAAAAAAAGAACTTGAAAAAATTGATATTGGAATTTATGCACTAACTT
CACTAGATAATTATCCTTACGATCCCGAATTTAATTTTTGTTCAAGATATCAAGTTCCTGTTTTTTCATATGTTTATGCA
TTAAACTTATTTGATTTTACTGATGTTATTCCACTTAATTTTGAAGTAACTGTTTATAAAGGGTATAATGCACATAATCT
TAAACCTAACACAATAGTTCACTATGTTAATAAAGAAATTTTTAATCTAGGAATTACTGAAATTAGAAATGCTTTTGGAA
ATTGGGTAAGAACCTATGATATTGAAAGAACAATTTGTGATCTTATTAAAAATAGAAAAAATATTAATGTTGAACTTTTT
GTAAAAACTATGAATAACTATGTTAATTATGAAAAAAAGGACTGGAATAAACTTTATGAATATGCTGAAAAAATGCACAT
TGAAAAAGAGCTAGTAGAAATATTTCAACTTATTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VPY9

Antitoxin

Source ID Structure
AlphaFold DB A0A829M395

References