Detailed information of TA system TA240095

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1997339..1997809
• Replicon: chromosome
• Accession: NZ_CP094729
• Organism: Staphylococcus epidermidis strain IVB6210

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: A0A939NNQ7
• Locus tag: MUA58_RS09430
• Protein ID: WP_002445998.1
• Coordinates: 1997621..1997809 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: A0A829M688
• Locus tag: MUA58_RS09425
• Protein ID: WP_002445999.1
• Coordinates: 1997339..1997596 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA58_RS09390 (MUA58_09390)	1992607..1993149	-	543	WP_002457219.1	nitroreductase	-
MUA58_RS09395 (MUA58_09395)	1993230..1993946	-	717	WP_002457220.1	type I 3-dehydroquinate dehydratase	-
MUA58_RS09400 (MUA58_09400)	1994107..1994529	+	423	WP_002457221.1	organic hydroperoxide resistance protein	-
MUA58_RS09405 (MUA58_09405)	1994935..1995435	+	501	WP_002457222.1	GNAT family N-acetyltransferase	-
MUA58_RS09410 (MUA58_09410)	1995706..1996293	-	588	WP_002457223.1	histidine phosphatase family protein	-
MUA58_RS09415 (MUA58_09415)	1996507..1996743	+	237	WP_002457224.1	hypothetical protein	-
MUA58_RS09420 (MUA58_09420)	1996735..1996938	-	204	WP_002457225.1	sterile alpha motif-like domain-containing protein	-
MUA58_RS09425 (MUA58_09425)	1997339..1997596	+	258	WP_002445999.1	hypothetical protein	Antitoxin
MUA58_RS09430 (MUA58_09430)	1997621..1997809	+	189	WP_002445998.1	hypothetical protein	Toxin
MUA58_RS09435 (MUA58_09435)	1997999..1998553	+	555	WP_002457226.1	lipoprotein N-acylation protein LnsA	-
MUA58_RS09440 (MUA58_09440)	1998612..1998845	-	234	WP_032604439.1	hypothetical protein	-
MUA58_RS09445 (MUA58_09445)	1999132..1999878	+	747	WP_002457228.1	poly-gamma-glutamate hydrolase family protein	-
MUA58_RS09450 (MUA58_09450)	1999977..2000261	+	285	WP_001829635.1	hypothetical protein	-
MUA58_RS09455 (MUA58_09455)	2000286..2000510	+	225	WP_002457229.1	hypothetical protein	-
MUA58_RS09460 (MUA58_09460)	2001131..2001331	-	201	WP_001829681.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (4-210)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (5-53)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7257.95 Da
• Isoelectric Point: 9.8369

>T240095 WP_002445998.1 NZ_CP094729:1997621-1997809 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKREERKESYLGFTVIFLIFGFAILIYTFIFGIL

Nucleotide

• Length: 189 bp

>T240095 NZ_LS483506:c1049325-1048591 [Mycoplasma mycoides subsp. capri]
CTGAAAAAAATATCTAAGAATAAGGATAAGATAAATATCATATTTAAAGGAGGTTTTTTGCTTTCTAATATAATTGGAAT
AAAAGAAAGAACAACCAAAGATATTGATTATTTATTAAATAACATTGTATTTTCACCTGATCGTATAAAAGAATTATTTG
AAGATATTTTAGATTATAAGAAAGGAGATAAAATACATTTTCAAATTCAAAAAATAAATGAAATTAAGAAAAAAGAAAAA
TATACAGGTTTTAGAATAACTGTAGAATGCAAATTAGATGAAATAGTAGAAATTATAAAAATAGATGTAGCAACAGGTGA
TATCATCACTTCCTGTCAAGTTAGATATAATATTGAAAATATTTTTCATAACAACAGTTTTTATGTTTATGGTTATAACT
TAGAAACTATGTTGGCTGAAAAAATTCATGCAATCAAAGAATTAAGCTTGTTTAATACTAGAACAAAAGATTTCTATGAT
ATATACCTAATTTATAATTTAAAAAGAGATGATATTGACTATATGACGTTGAAAAATGCTTGTATTAATACATTCAAACA
AAGAAACAGCATTTTTGATAAAGACGATTTATTAGAGTTACTCAATAAAATAAAAAATTCGCAATCTACTCATAATTTAT
GAACTAAACAAAAAAATATATATTTTTATAATAAAAACATAGATTTTAAATTTATCATTCAGTCAATTATTGAACTTATT
AAAAACATTAAATAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10014.05 Da
• Isoelectric Point: 4.5440

>AT240095 WP_002445999.1 NZ_CP094729:1997339-1997596 [Staphylococcus epidermidis]
MKLNKANVFNLIFTILFFTFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Nucleotide

• Length: 258 bp

>AT240095 NZ_LS483506:c1050024-1049425 [Mycoplasma mycoides subsp. capri]
ATGAACTATGTAGAAAAAATAAAAGAAAAAGCCATTCAAAATAATGGACTAATAACAAGAAAAGAAATTATAAGTCTAAA
AATCCCACCTATTTATATAACTAGAATGGTAAGAAAAAAAGAACTTGAAAAAATTGATATTGGAATTTATGCACTAACTT
CACTAGATAATTATCCTTACGATCCCGAATTTAATTTTTGTTCAAGATATCAAGTTCCTGTTTTTTCATATGTTTATGCA
TTAAACTTATTTGATTTTACTGATGTTATTCCACTTAATTTTGAAGTAACTGTTTATAAAGGGTATAATGCACATAATCT
TAAACCTAACACAATAGTTCACTATGTTAATAAAGAAATTTTTAATCTAGGAATTACTGAAATTAGAAATGCTTTTGGAA
ATTGGGTAAGAACCTATGATATTGAAAGAACAATTTGTGATCTTATTAAAAATAGAAAAAATATTAATGTTGAACTTTTT
GTAAAAACTATGAATAACTATGTTAATTATGAAAAAAAGGACTGGAATAAACTTTATGAATATGCTGAAAAAATGCACAT
TGAAAAAGAGCTAGTAGAAATATTTCAACTTATTATTTAA

Structures

Antitoxin

• AlphaFold DB: A0A829M688