Detailed information of TA system TA240094

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1005614..1006419
• Replicon: chromosome
• Accession: NZ_CP094729
• Organism: Staphylococcus epidermidis strain IVB6210

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: MUA58_RS04790
• Protein ID: WP_002457885.1
• Coordinates: 1006237..1006419 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A0E1VBD1
• Locus tag: MUA58_RS04785
• Protein ID: WP_002446763.1
• Coordinates: 1005614..1006213 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA58_RS04765 (MUA58_04760)	1001339..1002796	+	1458	WP_002457887.1	ABC transporter substrate-binding protein/permease	-
MUA58_RS04770 (MUA58_04765)	1002789..1003511	+	723	WP_002446766.1	amino acid ABC transporter ATP-binding protein	-
MUA58_RS04775 (MUA58_04770)	1003859..1004989	+	1131	WP_002457886.1	tRNA epoxyqueuosine(34) reductase QueG	-
MUA58_RS04780 (MUA58_04775)	1004986..1005456	+	471	WP_002446764.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MUA58_RS04785 (MUA58_04780)	1005614..1006213	+	600	WP_002446763.1	glucosamine-6-phosphate isomerase	Antitoxin
MUA58_RS04790 (MUA58_04785)	1006237..1006419	+	183	WP_002457885.1	SAS053 family protein	Toxin
MUA58_RS04795 (MUA58_04790)	1006571..1006975	+	405	WP_002457884.1	hypothetical protein	-
MUA58_RS04800 (MUA58_04795)	1007167..1008552	+	1386	WP_002447846.1	class II fumarate hydratase	-
MUA58_RS04805 (MUA58_04800)	1009027..1009509	+	483	Protein_912	transposase	-
MUA58_RS04810 (MUA58_04805)	1009683..1010507	-	825	WP_002457882.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1009198..1009509	311

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (125-195)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7080.67 Da
• Isoelectric Point: 4.3016

>T240094 WP_002457885.1 NZ_CP094729:1006237-1006419 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQPHDNEVRSDFKNSK

Nucleotide

• Length: 183 bp

>T240094 NZ_LS483505:c1056336-1055602 [Mycoplasma mycoides subsp. capri]
CTGAAAAAAATATCTAAGAATAAGGATAAGATAAATATCATATTTAAAGGAGGTTTTTTGCTTTCTAATATAATTGGAAT
AAAAGAAAGAACAACCAAAGATATTGATTATTTATTAAATAACATTGTATTTTCACCTGATCGTATAAAAGAATTATTTG
AAGATATTTTAGATTATAAGAAAGGAGATAAAATACATTTTCAAATTCAAAAAATAAATGAAATTAAGAAAAAAGAAAAA
TATACAGGTTTTAGAATAACTGTAGAATGCAAATTAGATGAAATAGTAGAAATTATAAAAATAGATGTAGCAACAGGTGA
TATCATCACTTCCTGTCAAGTTAGATATAATATTGAAAATATTTTTCATAACAACAGTTTTTATGTTTATGGTTATAACT
TAGAAACTATGTTGGCTGAAAAAATTCATGCAATCAAAGAATTAAGCTTGTTTAATACTAGAACAAAAGATTTCTATGAT
ATATACCTAATTTATAATTTAAAAAGAGATGATATTGACTATATGACGTTGAAAAATGCTTGTATTAATACATTCAAACA
AAGAAACAGCATTTTTGATAAAGACGATTTATTAGAGTTACTCAATAAAATAAAAAATTCGCAATCTACTCATAATTTAT
GAACTAAACAAAAAAATATATATTTTTATAATAAAAACATAGATTTTAAATTTATCATTCAGTCAATTATTGAACTTATT
AAAAACATTAAATAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22635.54 Da
• Isoelectric Point: 4.9942

>AT240094 WP_002446763.1 NZ_CP094729:1005614-1006213 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLGKEHAPVFDELKKNVENHAVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDVSVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT240094 NZ_LS483505:c1057035-1056436 [Mycoplasma mycoides subsp. capri]
ATGAACTATGTAGAAAAAATAAAAGAAAAAGCCATTCAAAATAATGGACTAATAACAAGAAAAGAAATTATAAGTCTAAA
AATCCCACCTATTTATATAACTAGAATGGTAAGAAAAAAAGAACTTGAAAAAATTGATATTGGAATTTATGCACTAACTT
CACTAGATAATTATCCTTACGATCCCGAATTTAATTTTTGTTCAAGATATCAAGTTCCTGTTTTTTCATATGTTTATGCA
TTAAACTTATTTGATTTTACTGATGTTATTCCACTTAATTTTGAAGTAACTGTTTATAAAGGGTATAATGCACATAATCT
TAAACCTAACACAATAGTTCACTATGTTAATAAAGAAATTTTTAATCTAGGAATTACTGAAATTAGAAATGCTTTTGGAA
ATTGGGTAAGAACCTATGATATTGAAAGAACAATTTGTGATCTTATTAAAAATAGAAAAAATATTAATGTTGAACTTTTT
GTAAAAACTATGAATAACTATGTTAATTATGAAAAAAAGGACTGGAATAAACTTTATGAATATGCTGAAAAAATGCACAT
TGAAAAAGAGCTAGTAGAAATATTTCAACTTATTATTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0E1VBD1