Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 858549..859078 Replicon chromosome
Accession NZ_CP094729
Organism Staphylococcus epidermidis strain IVB6210

Toxin (Protein)


Gene name mazF Uniprot ID A0A939SRT1
Locus tag MUA58_RS03950 Protein ID WP_002447757.1
Coordinates 858716..859078 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag MUA58_RS03945 Protein ID WP_001829931.1
Coordinates 858549..858719 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA58_RS03920 (MUA58_03915) 854373..854852 + 480 WP_002458695.1 PH domain-containing protein -
MUA58_RS03925 (MUA58_03920) 854845..856350 + 1506 WP_002458694.1 PH domain-containing protein -
MUA58_RS03930 (MUA58_03925) 856337..856855 + 519 WP_020363514.1 PH domain-containing protein -
MUA58_RS03935 (MUA58_03930) 856894..857247 + 354 WP_002458691.1 holo-ACP synthase -
MUA58_RS03940 (MUA58_03935) 857314..858462 + 1149 WP_002458690.1 alanine racemase -
MUA58_RS03945 (MUA58_03940) 858549..858719 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA58_RS03950 (MUA58_03945) 858716..859078 + 363 WP_002447757.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA58_RS03955 (MUA58_03950) 859423..860424 + 1002 WP_002447756.1 PP2C family protein-serine/threonine phosphatase -
MUA58_RS03960 (MUA58_03955) 860525..860851 + 327 WP_001829952.1 anti-sigma factor antagonist -
MUA58_RS03965 (MUA58_03960) 860853..861332 + 480 WP_262615068.1 anti-sigma B factor RsbW -
MUA58_RS03970 (MUA58_03965) 861307..862077 + 771 WP_002458689.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13483.62 Da        Isoelectric Point: 9.9522

>T240093 WP_002447757.1 NZ_CP094729:858716-859078 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSDSKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T240093 NZ_LS483504:c1053360-1052626 [Mycoplasma mycoides subsp. capri]
CTGAAAAAAATATCTAAGAATAAGGATAAGATAAATATCATATTTAAAGGAGGTTTTTTGCTTTCTAATATAATTGGAAT
AAAAGAAAGAACAACCAAAGATATTGATTATTTATTAAATAACATTGTATTTTCACCTGATCGTATAAAAGAATTATTTG
AAGATATTTTAGATTATAAGAAAGGAGATAAAATACATTTTCAAATTCAAAAAATAAATGAAATTAAGAAAAAAGAAAAA
TATACAGGTTTTAGAATAACTGTAGAATGCAAATTAGATGAAATAGTAGAAATTATAAAAATAGATGTAGCAACAGGTGA
TATCATCACTTCCTGTCAAGTTAGATATAATATTGAAAATATTTTTCATAACAACAGTTTTTATGTTTATGGTTATAACT
TAGAAACTATGTTGGCTGAAAAAATTCATGCAATCAAAGAATTAAGCTTGTTTAATACTAGAACAAAAGATTTCTATGAT
ATATACCTAATTTATAATTTAAAAAGAGATGATATTGACTATATGACGTTGAAAAATGCTTGTATTAATACATTCAAACA
AAGAAACAGCATTTTTGATAAAGACGATTTATTAGAGTTACTCAATAAAATAAAAAATTCGCAATCTACTCATAATTTAT
GAACTAAACAAAAAAATATATATTTTTATAATAAAAACATAGATTTTAAATTTATCATTCAGTCAATTATTGAACTTATT
AAAAACATTAAATAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT240093 WP_001829931.1 NZ_CP094729:858549-858719 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT240093 NZ_LS483504:c1054059-1053460 [Mycoplasma mycoides subsp. capri]
ATGAACTATGTAGAAAAAATAAAAGAAAAAGCCATTCAAAATAATGGACTAATAACAAGAAAAGAAATTATAAGTCTAAA
AATCCCACCTATTTATATAACTAGAATGGTAAGAAAAAAAGAACTTGAAAAAATTGATATTGGAATTTATGCACTAACTT
CACTAGATAATTATCCTTACGATCCCGAATTTAATTTTTGTTCAAGATATCAAGTTCCTGTTTTTTCATATGTTTATGCA
TTAAACTTATTTGATTTTACTGATGTTATTCCACTTAATTTTGAAGTAACTGTTTATAAAGGGTATAATGCACATAATCT
TAAACCTAACACAATAGTTCACTATGTTAATAAAGAAATTTTTAATCTAGGAATTACTGAAATTAGAAATGCTTTTGGAA
ATTGGGTAAGAACCTATGATATTGAAAGAACAATTTGTGATCTTATTAAAAATAGAAAAAATATTAATGTTGAACTTTTT
GTAAAAACTATGAATAACTATGTTAATTATGAAAAAAAGGACTGGAATAAACTTTATGAATATGCTGAAAAAATGCACAT
TGAAAAAGAGCTAGTAGAAATATTTCAACTTATTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References