Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2010680..2011150 Replicon chromosome
Accession NZ_CP094728
Organism Staphylococcus epidermidis strain IVB6213

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag MUA98_RS09525 Protein ID WP_001829569.1
Coordinates 2010962..2011150 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag MUA98_RS09520 Protein ID WP_002438963.1
Coordinates 2010680..2010937 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA98_RS09480 (MUA98_09445) 2006044..2006760 - 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -
MUA98_RS09485 (MUA98_09450) 2006921..2007343 + 423 WP_002457221.1 organic hydroperoxide resistance protein -
MUA98_RS09490 (MUA98_09455) 2007527..2007664 - 138 WP_162161215.1 hypothetical protein -
MUA98_RS09495 (MUA98_09460) 2007694..2007881 - 188 Protein_1837 hypothetical protein -
MUA98_RS09500 (MUA98_09465) 2008268..2008768 + 501 WP_001829623.1 GNAT family N-acetyltransferase -
MUA98_RS09505 (MUA98_09470) 2009039..2009626 - 588 WP_001829615.1 histidine phosphatase family protein -
MUA98_RS09510 (MUA98_09475) 2009840..2010076 + 237 WP_002457224.1 hypothetical protein -
MUA98_RS09515 (MUA98_09480) 2010068..2010271 - 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
MUA98_RS09520 (MUA98_09485) 2010680..2010937 + 258 WP_002438963.1 hypothetical protein Antitoxin
MUA98_RS09525 (MUA98_09490) 2010962..2011150 + 189 WP_001829569.1 hypothetical protein Toxin
MUA98_RS09530 (MUA98_09495) 2011340..2011894 + 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
MUA98_RS09535 (MUA98_09500) 2011954..2012187 - 234 WP_001829664.1 hypothetical protein -
MUA98_RS09540 (MUA98_09505) 2012471..2013217 + 747 WP_002438959.1 poly-gamma-glutamate hydrolase family protein -
MUA98_RS09545 (MUA98_09510) 2013316..2013600 + 285 WP_001829635.1 hypothetical protein -
MUA98_RS09550 (MUA98_09515) 2013624..2013848 + 225 WP_001829613.1 hypothetical protein -
MUA98_RS09555 (MUA98_09520) 2014469..2014669 - 201 WP_001829681.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2007527..2014669 7142
- flank IS/Tn - - 2007527..2007682 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(4-210)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(5-53)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T240091 WP_001829569.1 NZ_CP094728:2010962-2011150 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T240091 NZ_LS483501:c1055408-1054674 [Mycoplasma mycoides subsp. capri]
CTGAAAAAAATATCTAAGAATAAGGATAAGATAAATATCATATTTAAAGGAGGTTTTTTGCTTTCTAATATAATTGGAAT
AAAAGAAAGAACAACCAAAGATATTGATTATTTATTAAATAACATTGTATTTTCACCTGATCGTATAAAAGAATTATTTG
AAGATATTTTAGATTATAAGAAAGGAGATAAAATACATTTTCAAATTCAAAAAATAAATGAAATTAAGAAAAAAGAAAAA
TATACAGGTTTTAGAATAACTGTAGAATGCAAATTAGATGAAATAGTAGAAATTATAAAAATAGATGTAGCAACAGGTGA
TATCATCACTTCCTGTCAAGTTAGATATAATATTGAAAATATTTTTCATAACAACAGTTTTTATGTTTATGGTTATAACT
TAGAAACTATGTTGGCTGAAAAAATTCATGCAATCAAAGAATTAAGCTTGTTTAATACTAGAACAAAAGATTTCTATGAT
ATATACCTAATTTATAATTTAAAAAGAGATGATATTGACTATATGACGTTGAAAAATGCTTGTATTAATACATTCAAACA
AAGAAACAGCATTTTTGATAAAGACGATTTATTAGAGTTACTCAATAAAATAAAAAATTCGCAATCTACTCATAATTTAT
GAACTAAACAAAAAAATATATATTTTTATAATAAAAACATAGATTTTAAATTTATCATTCAGTCAATTATTGAACTTATT
AAAAACATTAAATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT240091 WP_002438963.1 NZ_CP094728:2010680-2010937 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT240091 NZ_LS483501:c1056107-1055508 [Mycoplasma mycoides subsp. capri]
ATGAACTATGTAGAAAAAATAAAAGAAAAAGCCATTCAAAATAATGGACTAATAACAAGAAAAGAAATTATAAGTCTAAA
AATCCCACCTATTTATATAACTAGAATGGTAAGAAAAAAAGAACTTGAAAAAATTGATATTGGAATTTATGCACTAACTT
CACTAGATAATTATCCTTACGATCCCGAATTTAATTTTTGTTCAAGATATCAAGTTCCTGTTTTTTCATATGTTTATGCA
TTAAACTTATTTGATTTTACTGATGTTATTCCACTTAATTTTGAAGTAACTGTTTATAAAGGGTATAATGCACATAATCT
TAAACCTAACACAATAGTTCACTATGTTAATAAAGAAATTTTTAATCTAGGAATTACTGAAATTAGAAATGCTTTTGGAA
ATTGGGTAAGAACCTATGATATTGAAAGAACAATTTGTGATCTTATTAAAAATAGAAAAAATATTAATGTTGAACTTTTT
GTAAAAACTATGAATAACTATGTTAATTATGAAAAAAAGGACTGGAATAAACTTTATGAATATGCTGAAAAAATGCACAT
TGAAAAAGAGCTAGTAGAAATATTTCAACTTATTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References