Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 865602..866131 Replicon chromosome
Accession NZ_CP094728
Organism Staphylococcus epidermidis strain IVB6213

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag MUA98_RS04025 Protein ID WP_001829891.1
Coordinates 865769..866131 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag MUA98_RS04020 Protein ID WP_001829931.1
Coordinates 865602..865772 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA98_RS03995 (MUA98_03965) 861426..861905 + 480 WP_010959254.1 PH domain-containing protein -
MUA98_RS04000 (MUA98_03970) 861898..863403 + 1506 WP_002457110.1 PH domain-containing protein -
MUA98_RS04005 (MUA98_03975) 863390..863899 + 510 WP_002457109.1 PH domain-containing protein -
MUA98_RS04010 (MUA98_03980) 863947..864300 + 354 WP_002457108.1 holo-ACP synthase -
MUA98_RS04015 (MUA98_03985) 864367..865515 + 1149 WP_002457107.1 alanine racemase -
MUA98_RS04020 (MUA98_03990) 865602..865772 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA98_RS04025 (MUA98_03995) 865769..866131 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA98_RS04030 (MUA98_04000) 866476..867477 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
MUA98_RS04035 (MUA98_04005) 867577..867903 + 327 WP_001829952.1 anti-sigma factor antagonist -
MUA98_RS04040 (MUA98_04010) 867905..868384 + 480 WP_001829903.1 anti-sigma B factor RsbW -
MUA98_RS04045 (MUA98_04015) 868359..869129 + 771 WP_262626042.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T240089 WP_001829891.1 NZ_CP094728:865769-866131 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T240089 NZ_LS483499:c3244308-3244057 [Tatumella ptyseos]
ATGAAAGCTGTCAGCTACAGTGAAGCACGTCAAAATCTCTCTGCAACAATGATTCAGACTGTTGAAGATAGATCCCCTAT
CCTGATCACCCGGCAGAACGGTGAATCATGTGTGTTGATGTCTCTTGAGGAATTCAATTCACTTGAAGAAACCGCTTATT
TATTGCGCTCTCCCAAAAATGCCCGCCGACTAATGGATTCAGTCGATAGCCTGAAAAATGGCAATGGTGTAGAAAGGAAT
GTCATTGAGTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT240089 WP_001829931.1 NZ_CP094728:865602-865772 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT240089 NZ_LS483499:c3244060-3243806 [Tatumella ptyseos]
GTGAAACTGATTTGGTCTGAAGAAGCGTGGGAAGATTATCTTTACTGGCAAAATGCGGATAAAAAGACAGTTAAAAAGAT
CAATGAACTTATCAAAGATGCCAGCAGAACTCCGTTTGAGGGGAAGGGTAAACCAGAGCCACTTAAATATAATCTTGCGG
GGTTTTGGTCCCGAAGGATAACGGCAGAACATCGATTTGTTTACGCTGTAAGCGATGATTCTCTGTTGATAGCATCTTGC
CGTTATCATTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References