240088

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 854417..854926 Replicon chromosome
Accession NZ_CP094728
Organism Staphylococcus epidermidis strain IVB6213

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag MUA98_RS03965 Protein ID WP_001829980.1
Coordinates 854717..854926 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag MUA98_RS03960 Protein ID WP_001829893.1
Coordinates 854417..854710 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA98_RS03935 (MUA98_03905) 849425..850213 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
MUA98_RS03940 (MUA98_03910) 850219..850857 + 639 WP_002505076.1 thiamine phosphate synthase -
MUA98_RS03945 (MUA98_03915) 850946..851818 + 873 WP_002458703.1 membrane protein insertase YidC -
MUA98_RS03950 (MUA98_03920) 851924..852577 - 654 WP_001829983.1 HD domain-containing protein -
MUA98_RS03955 (MUA98_03925) 852759..854243 - 1485 WP_002457116.1 cardiolipin synthase -
MUA98_RS03960 (MUA98_03930) 854417..854710 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA98_RS03965 (MUA98_03935) 854717..854926 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
MUA98_RS03970 (MUA98_03940) 855069..855206 + 138 WP_001829949.1 Lmo0850 family protein -
MUA98_RS03975 (MUA98_03945) 855305..856516 - 1212 WP_002486299.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA98_RS03980 (MUA98_03950) 856907..857980 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
MUA98_RS03985 (MUA98_03955) 857992..859347 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T240088 WP_001829980.1 NZ_CP094728:854717-854926 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T240088 NZ_LS483499:c3244060-3243806 [Tatumella ptyseos]
GTGAAACTGATTTGGTCTGAAGAAGCGTGGGAAGATTATCTTTACTGGCAAAATGCGGATAAAAAGACAGTTAAAAAGAT
CAATGAACTTATCAAAGATGCCAGCAGAACTCCGTTTGAGGGGAAGGGTAAACCAGAGCCACTTAAATATAATCTTGCGG
GGTTTTGGTCCCGAAGGATAACGGCAGAACATCGATTTGTTTACGCTGTAAGCGATGATTCTCTGTTGATAGCATCTTGC
CGTTATCATTACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT240088 WP_001829893.1 NZ_CP094728:854417-854710 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT240088 NZ_LS483499:c3244308-3244057 [Tatumella ptyseos]
ATGAAAGCTGTCAGCTACAGTGAAGCACGTCAAAATCTCTCTGCAACAATGATTCAGACTGTTGAAGATAGATCCCCTAT
CCTGATCACCCGGCAGAACGGTGAATCATGTGTGTTGATGTCTCTTGAGGAATTCAATTCACTTGAAGAAACCGCTTATT
TATTGCGCTCTCCCAAAAATGCCCGCCGACTAATGGATTCAGTCGATAGCCTGAAAAATGGCAATGGTGTAGAAAGGAAT
GTCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References