Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 1991699..1992169 | Replicon | chromosome |
| Accession | NZ_CP094726 | ||
| Organism | Staphylococcus epidermidis strain IVB6256 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | Q5HQS5 |
| Locus tag | MUA29_RS09390 | Protein ID | WP_001829569.1 |
| Coordinates | 1991981..1992169 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | D4FNP2 |
| Locus tag | MUA29_RS09385 | Protein ID | WP_002438963.1 |
| Coordinates | 1991699..1991956 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA29_RS09345 (MUA29_09320) | 1987067..1987783 | - | 717 | WP_001831974.1 | type I 3-dehydroquinate dehydratase | - |
| MUA29_RS09350 (MUA29_09325) | 1987944..1988366 | + | 423 | WP_002457221.1 | organic hydroperoxide resistance protein | - |
| MUA29_RS09355 (MUA29_09330) | 1988550..1988705 | - | 156 | WP_001829648.1 | hypothetical protein | - |
| MUA29_RS09360 (MUA29_09335) | 1988717..1988904 | - | 188 | Protein_1810 | hypothetical protein | - |
| MUA29_RS09365 (MUA29_09340) | 1989291..1989791 | + | 501 | WP_001829623.1 | GNAT family N-acetyltransferase | - |
| MUA29_RS09370 (MUA29_09345) | 1990061..1990648 | - | 588 | WP_262608232.1 | histidine phosphatase family protein | - |
| MUA29_RS09375 (MUA29_09350) | 1990861..1991097 | + | 237 | WP_002457224.1 | hypothetical protein | - |
| MUA29_RS09380 (MUA29_09355) | 1991089..1991292 | - | 204 | WP_002438966.1 | sterile alpha motif-like domain-containing protein | - |
| MUA29_RS09385 (MUA29_09360) | 1991699..1991956 | + | 258 | WP_002438963.1 | hypothetical protein | Antitoxin |
| MUA29_RS09390 (MUA29_09365) | 1991981..1992169 | + | 189 | WP_001829569.1 | hypothetical protein | Toxin |
| MUA29_RS09395 (MUA29_09370) | 1992359..1992913 | + | 555 | WP_064206171.1 | lipoprotein N-acylation protein LnsA | - |
| MUA29_RS09400 (MUA29_09375) | 1992973..1993206 | - | 234 | WP_001829664.1 | hypothetical protein | - |
| MUA29_RS09405 (MUA29_09380) | 1993491..1994237 | + | 747 | WP_064206170.1 | poly-gamma-glutamate hydrolase family protein | - |
| MUA29_RS09410 (MUA29_09385) | 1994336..1994620 | + | 285 | WP_002474308.1 | hypothetical protein | - |
| MUA29_RS09415 (MUA29_09390) | 1994645..1994869 | + | 225 | WP_017464630.1 | hypothetical protein | - |
| MUA29_RS09420 (MUA29_09395) | 1995491..1995691 | - | 201 | WP_001829681.1 | cold-shock protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1988550..1988705 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7229.94 Da Isoelectric Point: 9.7844
>T240087 WP_001829569.1 NZ_CP094726:1991981-1992169 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
Download Length: 189 bp
>T240087 NZ_LS483499:c1972415-1972083 [Tatumella ptyseos]
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTTGATCCTGTTGCAGGTCATGAACAAAGTGGAAAACGTCCGGTACTCAT
CGTTTCACCGGCTTCCTTCAATAAGCTGACCCGGCTACCCGTTGTTGTCCCCGTGACCAGCGGCGGAAACTTTGCCCGCG
CAGCTGGTTTTGCCGTTTCACTGGACGGGGCGGGAACAAAAACAGCGGGTATTATCCGCTGTGACCAGCCCAGAACAATT
GATATGGCTGCCCGCAACGGCAAACGGCTGGAACAGATACCTGACAGTATCGTGAATGAAGTGCTGGCCCGGCTGGAAGC
TATTTTGAACTGA
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTTGATCCTGTTGCAGGTCATGAACAAAGTGGAAAACGTCCGGTACTCAT
CGTTTCACCGGCTTCCTTCAATAAGCTGACCCGGCTACCCGTTGTTGTCCCCGTGACCAGCGGCGGAAACTTTGCCCGCG
CAGCTGGTTTTGCCGTTTCACTGGACGGGGCGGGAACAAAAACAGCGGGTATTATCCGCTGTGACCAGCCCAGAACAATT
GATATGGCTGCCCGCAACGGCAAACGGCTGGAACAGATACCTGACAGTATCGTGAATGAAGTGCTGGCCCGGCTGGAAGC
TATTTTGAACTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 10014.05 Da Isoelectric Point: 4.5440
>AT240087 WP_002438963.1 NZ_CP094726:1991699-1991956 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
Download Length: 258 bp
>AT240087 NZ_LS483499:c1972673-1972416 [Tatumella ptyseos]
ATGTATACCACTCGCCTGAAAAAAGTCGGCGGCTCTGTCATGCTGGCAGTCCCTCCCGCCGTGCTGAAAACGCTGGCGCT
GTCGACGGACAGCGAAGTAGGCATGACCATTGATAATGGCTGCCTGATTATTGAACCGCAAAAACGGCCTCGTTATTCGC
TTGATGAACTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCACCAGCGGTG
GGCAAGGAGATCCTGTAA
ATGTATACCACTCGCCTGAAAAAAGTCGGCGGCTCTGTCATGCTGGCAGTCCCTCCCGCCGTGCTGAAAACGCTGGCGCT
GTCGACGGACAGCGAAGTAGGCATGACCATTGATAATGGCTGCCTGATTATTGAACCGCAAAAACGGCCTCGTTATTCGC
TTGATGAACTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCACCAGCGGTG
GGCAAGGAGATCCTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0N0LUH8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0U5IVM3 |