Detailed information of TA system TA240086

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1030549..1031351
• Replicon: chromosome
• Accession: NZ_CP094726
• Organism: Staphylococcus epidermidis strain IVB6256

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: Q5HN83
• Locus tag: MUA29_RS04960
• Protein ID: WP_002468490.1
• Coordinates: 1031172..1031351 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: MUA29_RS04955
• Protein ID: WP_002476983.1
• Coordinates: 1030549..1031148 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA29_RS04930 (MUA29_04915)	1025760..1027217	+	1458	WP_002498152.1	ABC transporter substrate-binding protein/permease	-
MUA29_RS04935 (MUA29_04920)	1027210..1027932	+	723	WP_032603835.1	amino acid ABC transporter ATP-binding protein	-
MUA29_RS04940 (MUA29_04925)	1028430..1028579	+	150	WP_002468809.1	hypothetical protein	-
MUA29_RS04945 (MUA29_04930)	1028794..1029924	+	1131	WP_001829814.1	tRNA epoxyqueuosine(34) reductase QueG	-
MUA29_RS04950 (MUA29_04935)	1029921..1030391	+	471	WP_059223911.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MUA29_RS04955 (MUA29_04940)	1030549..1031148	+	600	WP_002476983.1	glucosamine-6-phosphate isomerase	Antitoxin
MUA29_RS04960 (MUA29_04945)	1031172..1031351	+	180	WP_002468490.1	SAS053 family protein	Toxin
MUA29_RS04965 (MUA29_04950)	1031507..1031911	+	405	WP_001829818.1	hypothetical protein	-
MUA29_RS04970 (MUA29_04955)	1032096..1033481	+	1386	WP_001829862.1	class II fumarate hydratase	-
MUA29_RS04975 (MUA29_04960)	1033842..1034666	-	825	WP_001829804.1	RluA family pseudouridine synthase	-
MUA29_RS04980 (MUA29_04965)	1034825..1035958	+	1134	WP_001829819.1	GAF domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6963.56 Da
• Isoelectric Point: 4.3016

>T240086 WP_002468490.1 NZ_CP094726:1031172-1031351 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Nucleotide

• Length: 180 bp

>T240086 NZ_LS483499:c991175-990957 [Tatumella ptyseos]
ATGAGTCAAACCCCATTAACCAAGACAGATTATCTGATGCGTCTGAGGCGCTGCCGATCGATCGATACTCTTGAGCGCGT
CATCGAAAAAAACAAATATGAACTCTCTGATGAAGATCTGGTGGTGTTTTATTCGGCCGCCGACCATCGCCTTGCTGAAC
TAACTATGAACAAATTGTACGATAAAGTGCCTGCCACCGTCTGGAAATATGTCCGTTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22679.60 Da
• Isoelectric Point: 4.9942

>AT240086 WP_002476983.1 NZ_CP094726:1030549-1031148 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHAVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT240086 NZ_LS483499:c991573-991193 [Tatumella ptyseos]
ATGGATGAATACTCACCTAAAAGATATGATGTAGCACAGCTTAAATTTTTGTGTGAAAATTTATTTGATGAAAGTCTGGC
TACCCTTAATCTCCAGGAGTTGTGCTGGATCAATGATCCGACATCGATAGAAAACCTACAGTTGCACGATTTAATTGAGC
ATATTGCAGCCGTCAGTATTATTTATAAATTAAAACATAGTGAAGATGAATTACTGATTTCACAGGTAGACAAATATCTT
GACGATACATTTACATTATTCAGTGGCTACACGGTAAATGAACAGGATTTAAATTACTGGAAAGCCTCGTCAAACAAATT
ATTTAGATTATTTTTTGAAGCGAGCCTCTGTCAGGAAAGCGGACAAAGTCTCACACATTAA

Structures

Toxin

• AlphaFold DB: A0A2G7HY44