240085

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 882427..882956 Replicon chromosome
Accession NZ_CP094726
Organism Staphylococcus epidermidis strain IVB6256

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag MUA29_RS04110 Protein ID WP_001829891.1
Coordinates 882594..882956 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag MUA29_RS04105 Protein ID WP_001829931.1
Coordinates 882427..882597 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA29_RS04080 (MUA29_04060) 878252..878731 + 480 WP_001829909.1 PH domain-containing protein -
MUA29_RS04085 (MUA29_04065) 878724..880229 + 1506 WP_001829976.1 PH domain-containing protein -
MUA29_RS04090 (MUA29_04070) 880216..880725 + 510 WP_001829888.1 PH domain-containing protein -
MUA29_RS04095 (MUA29_04075) 880773..881126 + 354 WP_001829915.1 holo-ACP synthase -
MUA29_RS04100 (MUA29_04080) 881192..882340 + 1149 WP_002468951.1 alanine racemase -
MUA29_RS04105 (MUA29_04085) 882427..882597 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA29_RS04110 (MUA29_04090) 882594..882956 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA29_RS04115 (MUA29_04095) 883302..884303 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
MUA29_RS04120 (MUA29_04100) 884403..884729 + 327 WP_001829952.1 anti-sigma factor antagonist -
MUA29_RS04125 (MUA29_04105) 884731..885210 + 480 WP_001829903.1 anti-sigma B factor RsbW -
MUA29_RS04130 (MUA29_04110) 885185..885955 + 771 WP_002468952.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T240085 WP_001829891.1 NZ_CP094726:882594-882956 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T240085 NZ_LS483498:c3741075-3740593 [Morganella morganii]
TTGCAGCAGCATCATGATTTTACCGTTTTTCAGTCAGGTGAGGAGTCCCTTAACCATTGGCTGAAAACCCGCGCATTGCA
AAATCAGCAATCCGGAGCCTCACGGACATTTGTCGTCTGCCACCATAACCGGATAATGGCCTATTATGCATTATCGACAG
GCGTTATTACCTGTTCACAGGCGGCGGGTCGTTTCAGACGTAATATGCCCCCGGAAATTCCGGTTATCCTGCCGGGACGT
CTTGCTGTTGACGAAAGCGTAAAAGGCAGAGGGATCGGACGGGGTCTGATAAAAGATGCCGCACTGCGGGTCTTGCAGGC
GGCCGGGATTGTGGGTATCCGCGGTATTGTTGTCCGTGCTCTGTCTGATAATGCCAGACGTTTTTATGAGCATACCGGTT
TTATGCCGTCACCGGCTGACCCGATGCTGCTGATGATTACATTACGGGATCTGCAGCTGGCAACCGGCATCTATTCTGAA
TAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT240085 WP_001829931.1 NZ_CP094726:882427-882597 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT240085 NZ_LS483498:c3741410-3741102 [Morganella morganii]
ATGACAAAACACACAGATGAGCAGCATCCTGTGTCCGGCGTGAATATCACCCGTTCAACACTGAATTTACGCATCAAACC
GGAAGATAAAATTCTGATTGATCGCGCAGCGCATGCTGCCGGTAAAAACAGAACCGAGTTCGTACTGGAAGCTGCGCGGC
GTGCCGCCGAAGAAACACTGGCAGATTTACGGGTTATTGATGTCAGTACCGATGTCTATCAGCAGTTTATTACCAGACTG
GATATGGCACCACAGTCCGGTGAGGCGCTGAAGAAGACCATGCTGACGAAGGCGCCGTGGGAGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References