Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 871244..871753 Replicon chromosome
Accession NZ_CP094726
Organism Staphylococcus epidermidis strain IVB6256

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag MUA29_RS04050 Protein ID WP_001829980.1
Coordinates 871544..871753 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag MUA29_RS04045 Protein ID WP_001829893.1
Coordinates 871244..871537 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA29_RS04020 (MUA29_04000) 866252..867040 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
MUA29_RS04025 (MUA29_04005) 867046..867684 + 639 WP_002505076.1 thiamine phosphate synthase -
MUA29_RS04030 (MUA29_04010) 867773..868645 + 873 WP_002458703.1 membrane protein insertase YidC -
MUA29_RS04035 (MUA29_04015) 868751..869404 - 654 WP_001829983.1 HD domain-containing protein -
MUA29_RS04040 (MUA29_04020) 869586..871070 - 1485 WP_002457116.1 cardiolipin synthase -
MUA29_RS04045 (MUA29_04025) 871244..871537 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA29_RS04050 (MUA29_04030) 871544..871753 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
MUA29_RS04055 (MUA29_04035) 871896..872033 + 138 WP_001829949.1 Lmo0850 family protein -
MUA29_RS04060 (MUA29_04040) 872133..873344 - 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA29_RS04065 (MUA29_04045) 873735..874808 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
MUA29_RS04070 (MUA29_04050) 874820..876175 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T240084 WP_001829980.1 NZ_CP094726:871544-871753 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T240084 NZ_LS483498:c906153-905950 [Morganella morganii]
ATGACTAAACTGGACTATCTCATGCGCTTACGTAAGTGCACTTCTATTGAAACACTGGAACGTGTCATTGAGAAAAACAA
ATATGAACTGACTGATGATGAGCTGGAGGTTTTTTATTCAGCAGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCATCTGTCTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT240084 WP_001829893.1 NZ_CP094726:871244-871537 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT240084 NZ_LS483498:c906576-906217 [Morganella morganii]
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACCCTCATCAGAAGCAATAATTATTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGGCCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCGTTTAATGACGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAGGGGCATCTTGTCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References