Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1071735..1072504 Replicon chromosome
Accession NZ_CP094725
Organism Staphylococcus felis strain IVB6254

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag MUA17_RS05100 Protein ID WP_180706696.1
Coordinates 1072352..1072504 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag MUA17_RS05095 Protein ID WP_115924746.1
Coordinates 1071735..1072334 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA17_RS05075 (MUA17_05080) 1067546..1069000 + 1455 WP_262633114.1 ABC transporter substrate-binding protein/permease -
MUA17_RS05080 (MUA17_05085) 1068993..1069715 + 723 WP_262633115.1 amino acid ABC transporter ATP-binding protein -
MUA17_RS05085 (MUA17_05090) 1070011..1071138 + 1128 WP_262633116.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA17_RS05090 (MUA17_05095) 1071141..1071611 + 471 WP_115856194.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA17_RS05095 (MUA17_05100) 1071735..1072334 + 600 WP_115924746.1 glucosamine-6-phosphate isomerase Antitoxin
MUA17_RS05100 (MUA17_05105) 1072352..1072504 + 153 WP_180706696.1 SAS053 family protein Toxin
MUA17_RS05105 (MUA17_05110) 1072617..1073015 + 399 WP_262633117.1 hypothetical protein -
MUA17_RS05110 (MUA17_05115) 1073178..1074563 + 1386 WP_103208495.1 class II fumarate hydratase -
MUA17_RS05115 (MUA17_05120) 1074585..1076111 + 1527 WP_115856191.1 exopolyphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-197)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5984.39 Da        Isoelectric Point: 3.8625

>T240083 WP_180706696.1 NZ_CP094725:1072352-1072504 [Staphylococcus felis]
MYQDKKDYDNEMVDGFDDMVELGKEMEQISEENDQEKLNQDHDQAVRSDK

Download         Length: 153 bp

>T240083 NZ_LS483498:417211-417531 [Morganella morganii]
ATGCATATTTCAACTGTACCGGTCACGGTGCCAGTTTCGTCACGCCTGTCGCCCGTGCAGGTCTGGCAGCAACTATTAAC
TTATCTGCTGGAACACTATTACGGTCTAACGCTAAACGACACACCATTCCATGATGATTCCGCCATCCAGGAACATATCG
AAGCGGGAATAACACTGGCTGATGCGGTGAACTTTCTGGTGGAACGCTACGAACTGATACGCACTGACCGCAAAGGGTTT
ACATGGCAAGGTCAGACACCATTTCTGACCGCTATCGATATTCTCAGAGCCAGGCGAGCTACCGGATTAATGAATATATA
A

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22341.42 Da        Isoelectric Point: 6.0821

>AT240083 WP_115924746.1 NZ_CP094725:1071735-1072334 [Staphylococcus felis]
MAMNFKIFKDADTAALYTADIIRKQFNNNPTTIAGIHLNNEDAPVLEALKKNVDDHAVDFSQIHILDYDKKTSYYKALGV
PEKQVHEIAEEEQVESFIEHHAKTKNNKGKLTLQVVTIDQKGYLGVGMKEGILPAREIILVITGDHKADLVKKLYEENGN
TSFIPSTLKQHRMVNVVLDEAAAQGLPEDVRSYFTSLYA

Download         Length: 600 bp

>AT240083 NZ_LS483498:416813-417169 [Morganella morganii]
ATGCAGTCGACCACCTTATCTGGCACATCGGCGGAGAACGCAACCTGCCTTCAGTGGGGATTAAAACGTAATATCACGCC
GTGCTTCGGCGCTCGCCTGGTACAGGAAGGCAACCGCCTATACTTTCTGGCTGACCGGGCGGGGTTTAATGGCTCATTCA
GTGACGATGAAGCATTGCGCCTAGATCAGGCGTTTCCACTAATAATGAAACAGTTAGAGCGGATGCTCACCACTGGAGAG
CTTGATCCCCGCAGTCAGCACTCCGTCGCTCTGCATCACAACGGACTTACTAGTGAAGCTGACACTCTCGGCTCTCATGG
CTACGTTTACATCGCTATTTACCCCAGTCAGCCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References