Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 927230..927760 Replicon chromosome
Accession NZ_CP094725
Organism Staphylococcus felis strain IVB6254

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MUA17_RS04265 Protein ID WP_103207265.1
Coordinates 927401..927760 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MUA17_RS04260 Protein ID WP_103207266.1
Coordinates 927230..927400 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA17_RS04235 (MUA17_04240) 923010..923483 + 474 WP_115871144.1 PH domain-containing protein -
MUA17_RS04240 (MUA17_04245) 923476..924993 + 1518 WP_103207272.1 PH domain-containing protein -
MUA17_RS04245 (MUA17_04250) 924974..925519 + 546 WP_103207271.1 PH domain-containing protein -
MUA17_RS04250 (MUA17_04255) 925516..925872 + 357 WP_103207269.1 holo-ACP synthase -
MUA17_RS04255 (MUA17_04260) 926000..927148 + 1149 WP_262633057.1 alanine racemase -
MUA17_RS04260 (MUA17_04265) 927230..927400 + 171 WP_103207266.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA17_RS04265 (MUA17_04270) 927401..927760 + 360 WP_103207265.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA17_RS04270 (MUA17_04275) 928007..929011 + 1005 WP_103207263.1 PP2C family protein-serine/threonine phosphatase -
MUA17_RS04275 (MUA17_04280) 929089..929415 + 327 WP_103207262.1 anti-sigma factor antagonist -
MUA17_RS04280 (MUA17_04285) 929418..929897 + 480 WP_103207378.1 anti-sigma B factor RsbW -
MUA17_RS04285 (MUA17_04290) 929872..930642 + 771 WP_103207260.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13331.49 Da        Isoelectric Point: 10.1421

>T240082 WP_103207265.1 NZ_CP094725:927401-927760 [Staphylococcus felis]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKQKYKLDKDSVILLEQIRT
VDKKRLKEKLTYLSDEKMKEVNNALGISLGLHMNQSKKD

Download         Length: 360 bp

>T240082 NZ_LS483496:c1523355-1523092 [Haemophilus influenzae]
ATGATTTCAGTGAGTGGGGAATATAAAAGAGAATTTAAAAAACATATTCCTCTTATTATAAATAGTCCAGAATATATTGA
AGTTATGTATTGTCTTTTGAATAGCTTACCATTGCCAGAAAAATATAAAGATCACGCTTTAACTGGCAATTGGAAAGGCT
GGCGAGATTGCCATATTAAGAATGATCTCGTGCTTATTTATAAAATTGTGGGGGATGAAATAAGATTAGCGCGTCTTAAT
ACCCATTCAGAAATTTTTGGTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6337.91 Da        Isoelectric Point: 4.0644

>AT240082 WP_103207266.1 NZ_CP094725:927230-927400 [Staphylococcus felis]
MSTFNQTRFKNNLEQSLKEGYVQMADLNLSLATEAYSVECEACDCNESHLTNSKDD

Download         Length: 171 bp

>AT240082 NZ_LS483496:c1523627-1523352 [Haemophilus influenzae]
ATGGCTGCAGTTAGCTTTCGAGTACCTGATGAAACTAAAAATATAGCGTTTGAAGTGATTAAAAGTTATGGTCTTTCCCC
AACTCAAGCACTTAATATGTTTTTAGCTCAAATAGCTAAAACGAAAGCGATTCCAGTATCATTAGATTATCAAACTGAAC
AGATGCCTAACTCAAAAACGATAATGGCTATGGCAGAGTTAGATAATCATCATAGGCATGAATACAAAACGTTGGAGGAA
TTTCATCAAGCGATGCTAGCGGAGATGAAATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References