Detailed information of TA system TA240080

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1798503..1798971
• Replicon: chromosome
• Accession: NZ_CP094724
• Organism: Staphylococcus hominis strain IVB6247

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: A0A533IU00
• Locus tag: MUA53_RS08910
• Protein ID: WP_002448257.1
• Coordinates: 1798783..1798971 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: A0A533IUW6
• Locus tag: MUA53_RS08905
• Protein ID: WP_002455569.1
• Coordinates: 1798503..1798760 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA53_RS08865 (MUA53_08850)	1793581..1793904	+	324	WP_002448188.1	thioredoxin family protein	-
MUA53_RS08870 (MUA53_08855)	1793942..1794481	-	540	WP_002448165.1	nitroreductase	-
MUA53_RS08875 (MUA53_08860)	1794551..1795276	-	726	WP_155974956.1	type I 3-dehydroquinate dehydratase	-
MUA53_RS08880 (MUA53_08865)	1795438..1795860	+	423	WP_002448074.1	organic hydroperoxide resistance protein	-
MUA53_RS08885 (MUA53_08870)	1796312..1796803	+	492	WP_002448223.1	GNAT family N-acetyltransferase	-
MUA53_RS08890 (MUA53_08875)	1796817..1797416	-	600	WP_262618124.1	histidine phosphatase family protein	-
MUA53_RS08895 (MUA53_08880)	1797611..1797853	+	243	WP_002448133.1	hypothetical protein	-
MUA53_RS08900 (MUA53_08885)	1797845..1798048	-	204	WP_002448195.1	sterile alpha motif-like domain-containing protein	-
MUA53_RS08905 (MUA53_08890)	1798503..1798760	+	258	WP_002455569.1	hypothetical protein	Antitoxin
MUA53_RS08910 (MUA53_08895)	1798783..1798971	+	189	WP_002448257.1	hypothetical protein	Toxin
MUA53_RS08915 (MUA53_08900)	1799140..1799634	+	495	WP_231117776.1	lipoprotein N-acylation protein LnsA	-
MUA53_RS08920 (MUA53_08905)	1799708..1800454	+	747	WP_262618128.1	poly-gamma-glutamate hydrolase family protein	-
MUA53_RS08925 (MUA53_08910)	1800531..1800815	+	285	WP_002448116.1	hypothetical protein	-
MUA53_RS08930 (MUA53_08915)	1800971..1801198	+	228	WP_070671707.1	hypothetical protein	-
MUA53_RS08935 (MUA53_08920)	1801331..1802047	+	717	WP_262618131.1	hypothetical protein	-
MUA53_RS08945 (MUA53_08930)	1803458..1803634	+	177	WP_002448052.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (41-89)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7064.73 Da
• Isoelectric Point: 9.6269

>T240080 WP_002448257.1 NZ_CP094724:1798783-1798971 [Staphylococcus hominis]
MSTHLTILLWLGIIFVVAASIILGLLLKSKKEERKESYLGFTVIFYIFGFALLIYILLFGIL

Nucleotide

• Length: 189 bp

>T240080 NZ_CP094724:1798783-1798971 [Staphylococcus hominis]
ATGAGTACACATTTAACGATTTTACTTTGGCTGGGTATTATATTTGTTGTTGCTGCTTCAATTATATTAGGGTTATTGCT
AAAATCTAAAAAAGAAGAACGTAAAGAATCATATTTAGGCTTTACAGTCATCTTCTATATTTTTGGTTTTGCTTTACTGA
TATATATACTATTATTCGGTATTTTATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10081.29 Da
• Isoelectric Point: 4.4986

>AT240080 WP_002455569.1 NZ_CP094724:1798503-1798760 [Staphylococcus hominis]
MNINKLFWINIMITLLFLGFNIIVTYFPKLDDYFWLIPGLIICGLTISFSLIAAILDKNLISEIIFLTNLIIFLYYIYPL
IYNFF

Nucleotide

• Length: 258 bp

>AT240080 NZ_CP094724:1798503-1798760 [Staphylococcus hominis]
ATGAATATTAATAAATTATTTTGGATTAATATTATGATTACCCTTTTATTTCTAGGTTTTAACATTATTGTCACCTATTT
TCCTAAGTTAGATGATTATTTCTGGCTCATACCTGGTTTAATCATATGTGGCCTCACTATTTCATTCAGTTTAATTGCCG
CTATCTTGGATAAAAACCTTATAAGCGAAATAATTTTTTTAACTAATCTAATCATTTTTTTATATTATATATATCCACTG
ATATATAACTTTTTTTAA

Structures

Toxin

• AlphaFold DB: A0A533IU00

Antitoxin

• AlphaFold DB: A0A533IUW6