Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 931891..932686 Replicon chromosome
Accession NZ_CP094724
Organism Staphylococcus hominis strain IVB6247

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag MUA53_RS04715 Protein ID WP_249339582.1
Coordinates 932513..932686 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag MUA53_RS04710 Protein ID WP_002449669.1
Coordinates 931891..932490 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA53_RS04690 (MUA53_04680) 927707..929161 + 1455 WP_155975544.1 ABC transporter substrate-binding protein/permease -
MUA53_RS04695 (MUA53_04685) 929154..929876 + 723 WP_049431519.1 amino acid ABC transporter ATP-binding protein -
MUA53_RS04700 (MUA53_04690) 930138..931259 + 1122 WP_049334938.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA53_RS04705 (MUA53_04695) 931261..931731 + 471 WP_002449676.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA53_RS04710 (MUA53_04700) 931891..932490 + 600 WP_002449669.1 glucosamine-6-phosphate isomerase Antitoxin
MUA53_RS04715 (MUA53_04705) 932513..932686 + 174 WP_249339582.1 SAS053 family protein Toxin
MUA53_RS04720 (MUA53_04710) 932797..933189 + 393 WP_002449658.1 hypothetical protein -
MUA53_RS04725 (MUA53_04715) 933330..934715 + 1386 WP_049334939.1 class II fumarate hydratase -
MUA53_RS04730 (MUA53_04720) 934794..935618 - 825 WP_155975545.1 RluA family pseudouridine synthase -
MUA53_RS04735 (MUA53_04725) 935756..936865 + 1110 WP_002455149.1 GAF domain-containing sensor histidine kinase -
MUA53_RS04740 (MUA53_04730) 936880..937503 + 624 WP_002449659.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6739.15 Da        Isoelectric Point: 3.9837

>T240079 WP_249339582.1 NZ_CP094724:932513-932686 [Staphylococcus hominis]
IFMSKDSKRNYHEDENAMVQNMDDLEALGKEMEQISEENDEDKYNQTHDSEARSDLN

Download         Length: 174 bp

>T240079 NZ_LS483496:245605-245913 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTAAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGCAATTTGGTACTGATTTACCAATACGTT
ATACAGGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22389.25 Da        Isoelectric Point: 4.9712

>AT240079 WP_002449669.1 NZ_CP094724:931891-932490 [Staphylococcus hominis]
MAMNFKVFEDKQHAADYAGDIIRKQFNNNPTTIAGFHLNKDSAPVLDELKKSVDRNAVDFSQINILDYDDNHSFYEALGV
PSEQVYSISLDDDAESLINDRIKTKENKGKLTLQVVSIDNTGHLDVNIRQGLMKAREIILVVTGAEKSEVIKRLYEENGK
SNFLPADLKVHRMVTVVLDRAAADGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT240079 NZ_LS483496:245309-245605 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGCAAACAAAATCAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTATTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTTTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References