240078

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 801540..802069 Replicon chromosome
Accession NZ_CP094724
Organism Staphylococcus hominis strain IVB6247

Toxin (Protein)


Gene name mazF Uniprot ID A0A4Q9WNP6
Locus tag MUA53_RS03940 Protein ID WP_017174798.1
Coordinates 801707..802069 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1L8Y5N2
Locus tag MUA53_RS03935 Protein ID WP_002448681.1
Coordinates 801540..801710 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA53_RS03910 (MUA53_03900) 797445..797924 + 480 WP_262619245.1 PH domain-containing protein -
MUA53_RS03915 (MUA53_03905) 797914..799416 + 1503 WP_262619480.1 PH domain-containing protein -
MUA53_RS03920 (MUA53_03910) 799409..799888 + 480 WP_262619247.1 PH domain-containing protein -
MUA53_RS03925 (MUA53_03915) 799913..800266 + 354 WP_019835621.1 holo-ACP synthase -
MUA53_RS03930 (MUA53_03920) 800309..801454 + 1146 WP_262619250.1 alanine racemase -
MUA53_RS03935 (MUA53_03925) 801540..801710 + 171 WP_002448681.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA53_RS03940 (MUA53_03930) 801707..802069 + 363 WP_017174798.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA53_RS03945 (MUA53_03935) 802441..803442 + 1002 WP_262619253.1 PP2C family protein-serine/threonine phosphatase -
MUA53_RS03950 (MUA53_03940) 803528..803854 + 327 WP_002448686.1 anti-sigma factor antagonist -
MUA53_RS03955 (MUA53_03945) 803883..804335 + 453 WP_049335593.1 anti-sigma B factor RsbW -
MUA53_RS03960 (MUA53_03950) 804310..805080 + 771 WP_002455074.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13580.74 Da        Isoelectric Point: 9.8760

>T240078 WP_017174798.1 NZ_CP094724:801707-802069 [Staphylococcus hominis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDDALDISLGLHDVRPQKN

Download         Length: 363 bp

>T240078 NZ_LS483496:c180221-179943 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAAGGTGTTCAGCAGGCTTATACAGA
CATTGGTGCGGTTTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATACCAATACAAATGAAGATATGGCAA
ACCTTTTTCAGGCAATGAATTCGCTAAAACAGTTGGCGTGGATTTCTCAGTCGGTACGAGATATTCGTGCTTTTCGTATT
GAGCAATGGTCTGACTTCACTGACTTTATACGAAGTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6368.03 Da        Isoelectric Point: 4.0121

>AT240078 WP_002448681.1 NZ_CP094724:801540-801710 [Staphylococcus hominis]
MLTFNQNRSHSLEQSLKEGYVQMADLNLSLATEAFPLECEACDCNESYLTSNYKSE

Download         Length: 171 bp

>AT240078 NZ_LS483496:c180421-180230 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACGGGCTGTATTAAACAATTCGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGCGATGCGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGATATTTATCGCTTAT
CTCACTTACTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Q9WNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A1L8Y5N2

References