240077

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 790523..791041 Replicon chromosome
Accession NZ_CP094724
Organism Staphylococcus hominis strain IVB6247

Toxin (Protein)


Gene name TsdT Uniprot ID A0A6B8SK15
Locus tag MUA53_RS03880 Protein ID WP_002448674.1
Coordinates 790832..791041 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A1L8Y5R0
Locus tag MUA53_RS03875 Protein ID WP_002437530.1
Coordinates 790523..790816 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA53_RS03850 (MUA53_03840) 785746..786534 + 789 WP_002448660.1 hydroxyethylthiazole kinase -
MUA53_RS03855 (MUA53_03845) 786537..787175 + 639 WP_048787784.1 thiamine phosphate synthase -
MUA53_RS03860 (MUA53_03850) 787264..788133 + 870 WP_002455066.1 membrane protein insertase YidC -
MUA53_RS03865 (MUA53_03855) 788191..788838 - 648 WP_002448635.1 HD domain-containing protein -
MUA53_RS03870 (MUA53_03860) 788873..790357 - 1485 WP_262619239.1 cardiolipin synthase -
MUA53_RS03875 (MUA53_03865) 790523..790816 + 294 WP_002437530.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA53_RS03880 (MUA53_03870) 790832..791041 + 210 WP_002448674.1 heavy metal-associated domain-containing protein Toxin
MUA53_RS03885 (MUA53_03875) 791154..791291 + 138 WP_002437525.1 Lmo0850 family protein -
MUA53_RS03890 (MUA53_03880) 791452..792636 - 1185 WP_262619242.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA53_RS03895 (MUA53_03885) 793012..794082 + 1071 WP_155975499.1 D-alanine--D-alanine ligase -
MUA53_RS03900 (MUA53_03890) 794098..795453 + 1356 WP_155975500.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-67)

Antitoxin

Metal-sensitive transcriptional repressor

(16-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7956.00 Da        Isoelectric Point: 4.0857

>T240077 WP_002448674.1 NZ_CP094724:790832-791041 [Staphylococcus hominis]
MLNSNIVFIDNIETEEQAQMLNERLLNMIGVHTVSIDIERNKINVEYETPTNLNSIEKEIYDAGFKVLS

Download         Length: 210 bp

>T240077 NZ_LS483492:2118504-2118600 [Serratia rubidaea]
AACAAGCCCTGCAATAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11231.84 Da        Isoelectric Point: 6.3270

>AT240077 WP_002437530.1 NZ_CP094724:790523-790816 [Staphylococcus hominis]
MENQNHAHHSEQVKLNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLEHHMKSCIMEKINQGTE
EEAMEELLVTFQKLVKD

Download         Length: 294 bp

>AT240077 NZ_LS483492:c2118601-2118487 [Serratia rubidaea]
TAAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTTATTGCAGGGCTTGTTCAGCCATGCACTTTAAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B8SK15

Antitoxin

Source ID Structure
AlphaFold DB A0A1L8Y5R0

References