Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1651761..1652283 Replicon chromosome
Accession NZ_CP094723
Organism Staphylococcus sp. IVB6214

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag MUA51_RS08120 Protein ID WP_262559302.1
Coordinates 1651761..1651982 (-) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag MUA51_RS08125 Protein ID WP_095117496.1
Coordinates 1651996..1652283 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA51_RS08100 (MUA51_08095) 1647765..1648970 + 1206 WP_262559298.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA51_RS08105 1649047..1649187 - 141 WP_262559299.1 Lmo0850 family protein -
MUA51_RS08110 (MUA51_08100) 1649273..1651453 - 2181 WP_262559300.1 heavy metal translocating P-type ATPase -
MUA51_RS08115 (MUA51_08105) 1651555..1651758 - 204 WP_262559301.1 cation transporter -
MUA51_RS08120 (MUA51_08110) 1651761..1651982 - 222 WP_262559302.1 heavy metal-associated domain-containing protein Toxin
MUA51_RS08125 (MUA51_08115) 1651996..1652283 - 288 WP_095117496.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA51_RS08130 (MUA51_08120) 1652427..1653917 + 1491 WP_262559303.1 cardiolipin synthase -
MUA51_RS08135 (MUA51_08125) 1653938..1654591 + 654 WP_262559305.1 HD domain-containing protein -
MUA51_RS08140 (MUA51_08130) 1654657..1655526 - 870 WP_262559307.1 membrane protein insertase YidC -
MUA51_RS08145 (MUA51_08135) 1655615..1656253 - 639 WP_262560887.1 thiamine phosphate synthase -
MUA51_RS08150 (MUA51_08140) 1656243..1657049 - 807 WP_262559308.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(20-65)

Antitoxin

Metal-sensitive transcriptional repressor

(12-90)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8159.08 Da        Isoelectric Point: 4.3344

>T240076 WP_262559302.1 NZ_CP094723:c1651982-1651761 [Staphylococcus sp. IVB6214]
VHSKVWLSGLSSEEQKQQLESRLSDMIGVEAVEVNIESQTVTLTYETPANLNTLEKEIYDAGYPVINSYKGAR

Download         Length: 222 bp

>T240076 NZ_LS483492:957921-958340 [Serratia rubidaea]
GTGGCCCAGTGGCGATGTGATGTCCGCATCTCCTGGCGTACTCAGCTTATCTCGTTGTTGGCGCATGGCGCGCTGATATT
GCTGATCCTGATTTCGCCGTGGCCGGAGAGTTACGATCCGGTCTGGCTGTTGCTGCTGACGCTGGTGGTTTTTGAATGTA
TTCGCAGTCAGACGCGTATCGCATCGCGCCAGGGGGAGCTGCGTCTGCTCTCTGCGCCGCAGCGGGTAATCTGGCAAGGC
AAGGAGTGGCGGCTGGTCCGGCGCCCATGGATGCTGCGCTATGGCATGCTGCTGACGCTGCAGGCGAGCGGAAAGCGTAA
ACGCCGGCGGCTGTGGCTGGCGTCGGACTGCATCAGCAGCGCGGAGTGGCGGCAGTTGTGCCAGCGGATGCGGCTGGTCA
AGGATGAATCTGAAGGCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10900.45 Da        Isoelectric Point: 6.7505

>AT240076 WP_095117496.1 NZ_CP094723:c1652283-1651996 [Staphylococcus sp. IVB6214]
MTEHANHSDVTKRNLQSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNGVASKLLEHHMKGCIMHKVEGGNEHE
AMDELLVTFQKLMKD

Download         Length: 288 bp

>AT240076 NZ_LS483492:957674-957940 [Serratia rubidaea]
ATGGATATTAATAACAAAGCGCGTATTCACTGGGCTTGCCGCCGTGGAATGCGTGAGCTGGACATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGATTCATTGAGCGAAGAGGATAAGGCGCTGTTCGTGCGTTTGTTGCAGTGTGACGATCCCGATC
TGTTTAACTGGCTGATGAATCATGGCGCCCCGCAGGACGCTGAATTGCAAAGAATGGTGACGCTGATCCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References