240075

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1638682..1639206 Replicon chromosome
Accession NZ_CP094723
Organism Staphylococcus sp. IVB6214

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MUA51_RS08050 Protein ID WP_095117482.1
Coordinates 1638682..1639035 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MUA51_RS08055 Protein ID WP_095117483.1
Coordinates 1639036..1639206 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA51_RS08030 (MUA51_08025) 1635761..1636534 - 774 WP_262559286.1 RNA polymerase sigma factor SigB -
MUA51_RS08035 (MUA51_08030) 1636506..1636988 - 483 WP_262559287.1 anti-sigma B factor RsbW -
MUA51_RS08040 (MUA51_08035) 1636990..1637316 - 327 WP_262559288.1 anti-sigma factor antagonist -
MUA51_RS08045 (MUA51_08040) 1637392..1638396 - 1005 WP_262559289.1 PP2C family protein-serine/threonine phosphatase -
MUA51_RS08050 (MUA51_08045) 1638682..1639035 - 354 WP_095117482.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA51_RS08055 (MUA51_08050) 1639036..1639206 - 171 WP_095117483.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA51_RS08060 (MUA51_08055) 1639295..1640443 - 1149 WP_262559291.1 alanine racemase -
MUA51_RS08065 (MUA51_08060) 1640471..1640830 - 360 WP_262559292.1 holo-ACP synthase -
MUA51_RS08070 (MUA51_08065) 1640827..1641390 - 564 WP_262559293.1 PH domain-containing protein -
MUA51_RS08075 (MUA51_08070) 1641380..1642885 - 1506 WP_262559294.1 PH domain-containing protein -
MUA51_RS08080 (MUA51_08075) 1642878..1643351 - 474 WP_262559295.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13030.17 Da        Isoelectric Point: 10.2682

>T240075 WP_095117482.1 NZ_CP094723:c1639035-1638682 [Staphylococcus sp. IVB6214]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIRT
VDKNRLKEKLTFLSDEKMKEVNNALGISLGLQVVQSR

Download         Length: 354 bp

>T240075 NZ_LS483491:c1613829-1613467 [Staphylococcus auricularis]
ATGATGAGACGAGGAGATGTATATTTAGCTGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGGCCTGTTGT
TATCATTCAAAATGATACTGGGAATAAATATAGTCCTACCGTAATTGTCGCTGCAATTACAGGTAGGATTAATAAAGCTA
AAATTCCAACCCATGTAGAAATAGACAAGAAGAAATATAAATTAGATAAAGATTCAGTTATCTTGTTAGAACAAATTCGA
ACATTAGATAAAAAGAGGCTGAAAGAGAAATTAACATATCTATCTGACGAGAAGATGGAAGAAGTAAATCGTGCTATCTT
CATAAGTTTAGGGTTACATAATATGAAACATTTCAAATCATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.02 Da        Isoelectric Point: 4.2313

>AT240075 WP_095117483.1 NZ_CP094723:c1639206-1639036 [Staphylococcus sp. IVB6214]
MSVFNQVKFKNLEQSLKEGYAQMADLNLSLATEAYSVECEACDCNESHLLSKHQDD

Download         Length: 171 bp

>AT240075 NZ_LS483491:c1613996-1613826 [Staphylococcus auricularis]
ATGTCTAATTTTAACACTACGAGATATCACAATATGGAGCAAATCTTAAAAGAAGGCTATTCACAAATGGCCGATCTTAA
TCTCTCCCTAGCAACAGAAGCTTTTCCTTTCGAATGTGAAGCTTGTGATTGTAACGAATCATTCCTCAGCTCCAATCACA
ATAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References