Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1476929..1477705 Replicon chromosome
Accession NZ_CP094723
Organism Staphylococcus sp. IVB6214

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag MUA51_RS07160 Protein ID WP_262559135.1
Coordinates 1476929..1477087 (-) Length 53 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag MUA51_RS07165 Protein ID WP_262559136.1
Coordinates 1477106..1477705 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA51_RS07145 (MUA51_07140) 1473164..1474690 - 1527 WP_262559131.1 exopolyphosphatase -
MUA51_RS07150 (MUA51_07145) 1474712..1476097 - 1386 WP_262559133.1 class II fumarate hydratase -
MUA51_RS07155 (MUA51_07150) 1476313..1476723 - 411 WP_262559134.1 hypothetical protein -
MUA51_RS07160 (MUA51_07155) 1476929..1477087 - 159 WP_262559135.1 SAS053 family protein Toxin
MUA51_RS07165 (MUA51_07160) 1477106..1477705 - 600 WP_262559136.1 glucosamine-6-phosphate isomerase Antitoxin
MUA51_RS07170 (MUA51_07165) 1477729..1478907 - 1179 WP_262559137.1 N-acetylglucosamine-6-phosphate deacetylase -
MUA51_RS07175 (MUA51_07170) 1478928..1479398 - 471 WP_262559138.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA51_RS07180 (MUA51_07175) 1479395..1480528 - 1134 WP_262559139.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA51_RS07185 (MUA51_07180) 1480687..1481409 - 723 WP_262559141.1 amino acid ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(132-195)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 6185.56 Da        Isoelectric Point: 3.9861

>T240074 WP_262559135.1 NZ_CP094723:c1477087-1476929 [Staphylococcus sp. IVB6214]
MNKQENEHGMVDSFEEVVELGKEMEQISEENDEQKFEQSHEEAVRSDRETDK

Download         Length: 159 bp

>T240074 NZ_LS483488:1486382-1486666 [Helicobacter pylori NCTC 11637 = CCUG 17874 = ATCC 43504]
ATGTATGCTTTAGCGTTTGATTTAAAGATTGAGATTTTAAAAAAAGAATACGGAGAACCCTACAATAAAGCCTATGATGA
TTTAAGGCAAGAATTAGAGCTATTAGGGTTTGAAAACACTCAAGGGAGCGTTTATGTTAATTATTCTAAAGAAAACACTT
TAGTGCAAGTCTATAAAGCGATCAATAAACTCTCTCAAATTGAGTGGTTTAAAAAGTCTGTTAGGGATATTAGAGCGTTT
AAGGTAGAGGACTTTAGCGATTTTACTGAGATTGTGAAATCCTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22187.23 Da        Isoelectric Point: 6.2339

>AT240074 WP_262559136.1 NZ_CP094723:c1477705-1477106 [Staphylococcus sp. IVB6214]
MAMNFKIFKDQGTAATFVADILRKQFNNNPTTIAGIHLKNDSVPVNAALQENVEKNPVDFSQIHILDYDKQTNYYKTLGV
PEKQIHEIPEDEKVESFIKHHAKTKENKGKLTLQVVTIDCDGNIGIPMNDGVLTAREVVLVLTGAEKAEVARKLYEENGS
TTFIPSSLKTHRMVNVVLDEAAAQGLPEDVRAYFTARYA

Download         Length: 600 bp

>AT240074 NZ_LS483488:1486009-1486401 [Helicobacter pylori NCTC 11637 = CCUG 17874 = ATCC 43504]
ATGCCAAACACCACCGCAGAAAAAGACTACACAAAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCATGAGATCCCAAACATTCAAACGCAACAAGCCATGAGAGATGCGGTGAATGGGGTTAATCTCACTCAAATTGATAA
TTTAGATGATCTTACAAACGAGTTAAAAAGAGAAAATAATAAAGGTTTTGAAAATGTATGCTTTAGCGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References