Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1693746..1694268 Replicon chromosome
Accession NZ_CP094722
Organism Staphylococcus sp. IVB6218

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag MUA65_RS08485 Protein ID WP_262609113.1
Coordinates 1693746..1693967 (-) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag MUA65_RS08490 Protein ID WP_262603714.1
Coordinates 1693981..1694268 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA65_RS08465 (MUA65_08450) 1689747..1690952 + 1206 WP_262603710.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA65_RS08470 (MUA65_08455) 1691033..1691173 - 141 WP_262605150.1 Lmo0850 family protein -
MUA65_RS08475 (MUA65_08460) 1691259..1693439 - 2181 WP_262603711.1 heavy metal translocating P-type ATPase -
MUA65_RS08480 (MUA65_08465) 1693540..1693743 - 204 WP_262603712.1 cation transporter -
MUA65_RS08485 (MUA65_08470) 1693746..1693967 - 222 WP_262609113.1 heavy metal-associated domain-containing protein Toxin
MUA65_RS08490 (MUA65_08475) 1693981..1694268 - 288 WP_262603714.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA65_RS08495 (MUA65_08480) 1694412..1695902 + 1491 WP_262609114.1 cardiolipin synthase -
MUA65_RS08500 (MUA65_08485) 1695923..1696573 + 651 WP_262609115.1 HD domain-containing protein -
MUA65_RS08505 (MUA65_08490) 1696636..1697505 - 870 WP_262603717.1 membrane protein insertase YidC -
MUA65_RS08510 (MUA65_08495) 1697594..1698232 - 639 WP_262605151.1 thiamine phosphate synthase -
MUA65_RS08515 (MUA65_08500) 1698222..1699028 - 807 WP_262603718.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(5-63)

Antitoxin

Metal-sensitive transcriptional repressor

(12-90)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8299.26 Da        Isoelectric Point: 4.1813

>T240073 WP_262609113.1 NZ_CP094722:c1693967-1693746 [Staphylococcus sp. IVB6218]
VHSKVWLSGLSSEEQKQQLESRLRDMIGVETAEVDIDKQIVILTYETPANLNTLEKEIYDAGYPVINSYKGED

Download         Length: 222 bp

>T240073 NZ_LS483488:c121868-121587 [Helicobacter pylori NCTC 11637 = CCUG 17874 = ATCC 43504]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAACATATCTTGTCTGGGCGTATTACAGAAAGCGA
TGTTACAAGCATTGTTGATTGCCTCAAAGAGCAAAAACCGCTCCAACAAAAATATTGCGACCATGCCTTGAGTGGCAATC
TTAAAGGGCTGAGAGAGTGTCATGTCAAGCCGAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10929.52 Da        Isoelectric Point: 6.6368

>AT240073 WP_262603714.1 NZ_CP094722:c1694268-1693981 [Staphylococcus sp. IVB6218]
MIEHANHSEVTKRNLQSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVASKLLEHHMKGCILHKVEGGNEQE
AMDELLVTFQKLMKD

Download         Length: 288 bp

>AT240073 NZ_LS483488:c122175-121861 [Helicobacter pylori NCTC 11637 = CCUG 17874 = ATCC 43504]
ATGTCAAATATTATTACAGATTACTCACAATACAATGAAAAGCAACTGCAACATTTTTTAAACTCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAATAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACCAAGTTTGTTGAATACGATCGCCTCAAAAGATGACCCAGAA
TACGATGTTTCGTTTGGAGACTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References