Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1679462..1679986 Replicon chromosome
Accession NZ_CP094722
Organism Staphylococcus sp. IVB6218

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MUA65_RS08410 Protein ID WP_262603700.1
Coordinates 1679462..1679815 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MUA65_RS08415 Protein ID WP_095117483.1
Coordinates 1679816..1679986 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA65_RS08390 (MUA65_08375) 1676514..1677287 - 774 WP_262603697.1 RNA polymerase sigma factor SigB -
MUA65_RS08395 (MUA65_08380) 1677259..1677741 - 483 WP_262603698.1 anti-sigma B factor RsbW -
MUA65_RS08400 (MUA65_08385) 1677743..1678069 - 327 WP_262603699.1 anti-sigma factor antagonist -
MUA65_RS08405 (MUA65_08390) 1678146..1679117 - 972 WP_262605955.1 PP2C family protein-serine/threonine phosphatase -
MUA65_RS08410 (MUA65_08395) 1679462..1679815 - 354 WP_262603700.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA65_RS08415 (MUA65_08400) 1679816..1679986 - 171 WP_095117483.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA65_RS08420 (MUA65_08405) 1680075..1681223 - 1149 WP_262609109.1 alanine racemase -
MUA65_RS08425 (MUA65_08410) 1681277..1681627 - 351 WP_262603702.1 holo-ACP synthase -
MUA65_RS08430 (MUA65_08415) 1681630..1682199 - 570 WP_262609110.1 PH domain-containing protein -
MUA65_RS08435 (MUA65_08420) 1682174..1683688 - 1515 WP_262609111.1 PH domain-containing protein -
MUA65_RS08440 (MUA65_08425) 1683681..1684154 - 474 WP_262603705.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13072.25 Da        Isoelectric Point: 10.3952

>T240072 WP_262603700.1 NZ_CP094722:c1679815-1679462 [Staphylococcus sp. IVB6218]
MKRGDVYLADLSPVRGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIRT
VDKNRLKEKLTFLSEEKMKEVNNALGISLGLQVVQSR

Download         Length: 354 bp

>T240072 NZ_LS483486:c1669210-1668962 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCTCACCCTGAAAATTATATTAAAGGTGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.02 Da        Isoelectric Point: 4.2313

>AT240072 WP_095117483.1 NZ_CP094722:c1679986-1679816 [Staphylococcus sp. IVB6218]
MSVFNQVKFKNLEQSLKEGYAQMADLNLSLATEAYSVECEACDCNESHLLSKHQDD

Download         Length: 171 bp

>AT240072 NZ_LS483486:c1668965-1668621 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTGTTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References