Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1567608..1568390 Replicon chromosome
Accession NZ_CP094722
Organism Staphylococcus sp. IVB6218

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA65_RS07835 Protein ID WP_262619695.1
Coordinates 1567935..1568390 (+) Length 152 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA65_RS07830 Protein ID WP_262619694.1
Coordinates 1567608..1567922 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA65_RS07765 (MUA65_07750) 1562863..1563015 - 153 WP_262619685.1 hypothetical protein -
MUA65_RS07770 (MUA65_07755) 1563091..1563264 - 174 WP_262619686.1 hypothetical protein -
MUA65_RS07775 (MUA65_07760) 1563194..1563361 - 168 WP_262619687.1 hypothetical protein -
MUA65_RS07780 (MUA65_07765) 1563504..1563743 + 240 WP_262609059.1 hypothetical protein -
MUA65_RS07785 (MUA65_07770) 1563733..1563912 - 180 WP_262619688.1 hypothetical protein -
MUA65_RS07790 (MUA65_07775) 1564003..1564383 + 381 WP_262609061.1 DUF2513 domain-containing protein -
MUA65_RS07795 (MUA65_07780) 1564370..1564567 - 198 WP_262609062.1 hypothetical protein -
MUA65_RS07800 (MUA65_07785) 1564617..1564952 + 336 WP_262619689.1 hypothetical protein -
MUA65_RS07805 (MUA65_07790) 1564938..1565171 - 234 WP_262619690.1 DUF2829 domain-containing protein -
MUA65_RS07810 (MUA65_07795) 1565207..1565974 - 768 WP_262619691.1 phage antirepressor -
MUA65_RS07815 (MUA65_07800) 1565989..1566432 - 444 WP_262613895.1 hypothetical protein -
MUA65_RS07820 (MUA65_07805) 1566448..1567203 - 756 WP_262619692.1 phage antirepressor KilAC domain-containing protein -
MUA65_RS07825 (MUA65_07810) 1567219..1567455 - 237 WP_262619693.1 helix-turn-helix transcriptional regulator -
MUA65_RS07830 (MUA65_07815) 1567608..1567922 + 315 WP_262619694.1 helix-turn-helix transcriptional regulator Antitoxin
MUA65_RS07835 (MUA65_07820) 1567935..1568390 + 456 WP_262619695.1 ImmA/IrrE family metallo-endopeptidase Toxin
MUA65_RS07840 (MUA65_07825) 1568439..1569215 + 777 WP_262619696.1 hypothetical protein -
MUA65_RS07845 (MUA65_07830) 1569398..1570051 + 654 WP_262619697.1 CPBP family intramembrane metalloprotease -
MUA65_RS07850 (MUA65_07835) 1570119..1571513 + 1395 WP_262619698.1 recombinase family protein -
MUA65_RS07855 (MUA65_07840) 1571527..1572402 - 876 Protein_1503 PTS transporter subunit EIIC -
MUA65_RS07860 (MUA65_07845) 1572402..1572719 - 318 WP_262603623.1 lactose-specific PTS transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1526937..1573571 46634


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(32-116)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 152 a.a.        Molecular weight: 17850.41 Da        Isoelectric Point: 6.0090

>T240071 WP_262619695.1 NZ_CP094722:1567935-1568390 [Staphylococcus sp. IVB6218]
MGLYEETLIQHDYIEVREANVLPDDLDGVWLGDLILIKRNLPEKKKVEVLFEELAHHKLTYGDITNQKQFNNRKFENYAR
RYSYETSMPLSGIVEAFKQGVRNLYELANFFEITEGHVLDCIAHYKKKYGLQVKQGDYLIRFEPLTIYKDV

Download         Length: 456 bp

>T240071 NZ_LS483486:1291986-1292291 [Haemophilus influenzae]
ATGTTTAATTTAAAGCGTGAGCATTTTAGAGATGATTATCTTTATAGGTTTTATCAATATGGTGATACTCATAGTAAGAT
TCCTTCTAATTTGTATAAAGTATTGGCAAGAAAATTAGATATGATAAGTGCCTCAGAAAATATCAACGATTTACGTTCTC
CACCAGCTAACCATTTGGAGTTGCTTGAGCCAAAAGAAAATAAAATTTATTCTATTCGAGTGAATAAACAATATCGTTTA
ATTTTTAAATATGAAAATAACGAAGTAAATAATTTATATTTAGATCCACATTCTTATAATTTGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12117.66 Da        Isoelectric Point: 8.0157

>AT240071 WP_262619694.1 NZ_CP094722:1567608-1567922 [Staphylococcus sp. IVB6218]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIAEALNVNPAYLMGWIDKDNDEVQHRAAHL
EGNLTDEEWQRVLDYADYIRSRRK

Download         Length: 315 bp

>AT240071 NZ_LS483486:1292302-1292625 [Haemophilus influenzae]
ATGATGACGAGAAAACCCACCTCTGTTGGTGAAATTCTACAAGAAGAGTTTTTAGAACCTTTAAGTCTTAAAATTAGTGA
TTTAGCTCAAATTTTAGATGTACATCGTAATACGGCAAGCAATATTGTTAATAATAGTTCACGAATTACGCTAGAAATGG
CAGTTAAACTTGCTAAAGTATTTGATACTACGCCTGAGTTTTGGCTTAATCTGCAAACACGTATTGATTTATGGGACCTT
GAACACAATAAACGTTTTCAACAAAGTCTTGCAAATGTTAAGCCCGCTCTACATCGGCATGATACTTCTACATTTGCAAT
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References