Detailed information of TA system TA240070

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1459695..1460471
• Replicon: chromosome
• Accession: NZ_CP094722
• Organism: Staphylococcus sp. IVB6218

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: MUA65_RS07085
• Protein ID: WP_262603510.1
• Coordinates: 1459695..1459853 (-)
• Length: 53 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: MUA65_RS07090
• Protein ID: WP_262603511.1
• Coordinates: 1459872..1460471 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA65_RS07070 (MUA65_07055)	1455809..1457335	-	1527	WP_262609017.1	exopolyphosphatase	-
MUA65_RS07075 (MUA65_07060)	1457357..1458742	-	1386	WP_262603508.1	class II fumarate hydratase	-
MUA65_RS07080 (MUA65_07065)	1458924..1459328	-	405	WP_262603509.1	hypothetical protein	-
MUA65_RS07085 (MUA65_07070)	1459695..1459853	-	159	WP_262603510.1	SAS053 family protein	Toxin
MUA65_RS07090 (MUA65_07075)	1459872..1460471	-	600	WP_262603511.1	glucosamine-6-phosphate isomerase	Antitoxin
MUA65_RS07095 (MUA65_07080)	1460498..1461670	-	1173	WP_262605317.1	N-acetylglucosamine-6-phosphate deacetylase	-
MUA65_RS07100 (MUA65_07085)	1461691..1462161	-	471	WP_262605318.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MUA65_RS07105 (MUA65_07090)	1462161..1463291	-	1131	WP_262609574.1	tRNA epoxyqueuosine(34) reductase QueG	-
MUA65_RS07110 (MUA65_07095)	1463507..1464229	-	723	WP_262603514.1	amino acid ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (131-195)

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 6189.45 Da
• Isoelectric Point: 3.8145

>T240070 WP_262603510.1 NZ_CP094722:c1459853-1459695 [Staphylococcus sp. IVB6218]
MNKQENEHGMVDSFDEVVELGKEMEQISEENDEEKYEQSHEEAVRSDRETDE

Nucleotide

• Length: 159 bp

>T240070 NZ_LS483486:962971-963189 [Haemophilus influenzae]
GTGGGTATAATAACCACCATTGAAAGGCAAGAGGGAGAAACAGTGGATAGCAAAACAGCAATAAAAATGATAGAAGAGGA
CGGTTGGTATTTAGATAGAGTTAAAGGTAGTCATCATCAATACAAACATCCTACAAAAAAGGGAACGGTCACGATTCCCC
ACCCAAGGAAAGACTTGGGGCATTTAGAAAAAAGCATTAAAAAACAAGCGGGGCTGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22037.03 Da
• Isoelectric Point: 5.6098

>AT240070 WP_262603511.1 NZ_CP094722:c1460471-1459872 [Staphylococcus sp. IVB6218]
MAMNFKIFKDQNTAATFVADILRKQFSNNPTTIAGIHLKNDDAPVNGALQINVENNPVDFSQIHILDYDKNDAYFKALGV
PEKQIHEIPEDEKVEAFIKHHAKTKENKGKLTLQVVTIDTDGSIGIPMNDAVLTAREIVLVLTGAEKAEVVRKLYEENGS
TTFVPSSLKSHRMVNVVLDEAAAQGLPEDVRAYFSARFA

Nucleotide

• Length: 600 bp

>AT240070 NZ_LS483486:963217-963618 [Haemophilus influenzae]
ATGTTATACCCAATTTGTATCGAAAAAGTAAATGATGGTTATGTGGTATCTGTGCCAGATGTGCCAGGCTGTTTTTCTGC
TGGGGATACCTTATCAGAAGCAATGTTAAACGCAAAAGAAGCAATCTCTTTTCACATTGAAGGGATGTTAGAAGATGATG
AAGAATTGCCTAAATCTAACCCAATAGAACAATATATTAATCAGCCCGAATATAAAGATTTTATTGTCACTGTTGTTGAT
GTAGATTTAACTCATTTAATGGGTAAGGCGGAAAAAATTAATATTACGGTTCCAGCGTTATTACTGCACCGCATTGATCA
GTTTATTGCCACTCATCCAGAATATAAGAATAGAAGTAACTTTTTGTCTCAACTAGCAACAAATAGATTACTTTCTGCAT
AA