Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1341184..1341670 Replicon chromosome
Accession NC_012926
Organism Streptococcus suis BM407

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag SSUBM407_RS06575 Protein ID WP_011922754.1
Coordinates 1341184..1341453 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag SSUBM407_RS06580 Protein ID WP_002938604.1
Coordinates 1341443..1341670 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSUBM407_RS06550 1336237..1337154 - 918 WP_002937252.1 DNA-binding protein WhiA -
SSUBM407_RS06555 1337151..1338125 - 975 WP_002937257.1 YvcK family protein -
SSUBM407_RS06560 1338122..1339009 - 888 WP_011922160.1 RNase adapter RapZ -
SSUBM407_RS06565 1339031..1339408 - 378 WP_002937263.1 RidA family protein -
SSUBM407_RS06570 1339459..1340778 - 1320 WP_012775027.1 MATE family efflux transporter -
SSUBM407_RS06575 1341184..1341453 - 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSUBM407_RS06580 1341443..1341670 - 228 WP_002938604.1 hypothetical protein Antitoxin
SSUBM407_RS06585 1341942..1343288 - 1347 WP_012775642.1 asparagine--tRNA ligase -
SSUBM407_RS06590 1343303..1344484 - 1182 WP_011922154.1 pyridoxal phosphate-dependent aminotransferase -
SSUBM407_RS06595 1344481..1344978 - 498 WP_011922751.1 DUF5590 domain-containing protein -
SSUBM407_RS06605 1346178..1346627 + 450 WP_009909619.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T24007 WP_011922754.1 NC_012926:c1341453-1341184 [Streptococcus suis BM407]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T24007 NC_012926:c1341453-1341184 [Streptococcus suis BM407]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT24007 WP_002938604.1 NC_012926:c1341670-1341443 [Streptococcus suis BM407]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT24007 NC_012926:c1341670-1341443 [Streptococcus suis BM407]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References