Detailed information of TA system TA240069

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 1688182..1688704
• Replicon: chromosome
• Accession: NZ_CP094721
• Organism: Staphylococcus sp. IVB6227

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: MUA92_RS08400
• Protein ID: WP_262559302.1
• Coordinates: 1688182..1688403 (-)
• Length: 74 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: MUA92_RS08405
• Protein ID: WP_095117496.1
• Coordinates: 1688417..1688704 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA92_RS08380 (MUA92_08380)	1684186..1685391	+	1206	WP_262559298.1	FtsW/RodA/SpoVE family cell cycle protein	-
MUA92_RS08385	1685468..1685608	-	141	WP_262615927.1	Lmo0850 family protein	-
MUA92_RS08390 (MUA92_08385)	1685694..1687874	-	2181	WP_262559300.1	heavy metal translocating P-type ATPase	-
MUA92_RS08395 (MUA92_08390)	1687976..1688179	-	204	WP_262559301.1	cation transporter	-
MUA92_RS08400 (MUA92_08395)	1688182..1688403	-	222	WP_262559302.1	heavy metal-associated domain-containing protein	Toxin
MUA92_RS08405 (MUA92_08400)	1688417..1688704	-	288	WP_095117496.1	copper-sensing transcriptional repressor CsoR	Antitoxin
MUA92_RS08410 (MUA92_08405)	1688848..1690338	+	1491	WP_262559303.1	cardiolipin synthase	-
MUA92_RS08415 (MUA92_08410)	1690359..1691009	+	651	WP_262615436.1	HD domain-containing protein	-
MUA92_RS08420 (MUA92_08415)	1691075..1691944	-	870	WP_262559307.1	membrane protein insertase YidC	-
MUA92_RS08425 (MUA92_08420)	1692033..1692671	-	639	WP_262560887.1	thiamine phosphate synthase	-
MUA92_RS08430 (MUA92_08425)	1692661..1693467	-	807	WP_262559308.1	hydroxyethylthiazole kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (20-65)

Antitoxin

• Metal-sensitive transcriptional repressor (12-90)

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8159.08 Da
• Isoelectric Point: 4.3344

>T240069 WP_262559302.1 NZ_CP094721:c1688403-1688182 [Staphylococcus sp. IVB6227]
VHSKVWLSGLSSEEQKQQLESRLSDMIGVEAVEVNIESQTVTLTYETPANLNTLEKEIYDAGYPVINSYKGAR

Nucleotide

• Length: 222 bp

>T240069 NZ_LS483486:c744895-744491 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTATTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATGAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTGAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGCGACCTATCGGAAATAATGATCTATGGATCGCTTGTCACGCATT
GAGTTTAAATGCCGTTCTTATTACACATAATGTAAAAGAATTTCAGCGAATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10900.45 Da
• Isoelectric Point: 6.7505

>AT240069 WP_095117496.1 NZ_CP094721:c1688704-1688417 [Staphylococcus sp. IVB6227]
MTEHANHSDVTKRNLQSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNGVASKLLEHHMKGCIMHKVEGGNEHE
AMDELLVTFQKLMKD

Nucleotide

• Length: 288 bp

>AT240069 NZ_LS483486:c745128-744892 [Haemophilus influenzae]
ATGCTTACTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGACGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA