Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1675103..1675627 Replicon chromosome
Accession NZ_CP094721
Organism Staphylococcus sp. IVB6227

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MUA92_RS08330 Protein ID WP_095117482.1
Coordinates 1675103..1675456 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MUA92_RS08335 Protein ID WP_095117483.1
Coordinates 1675457..1675627 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA92_RS08310 (MUA92_08310) 1672182..1672955 - 774 WP_262559286.1 RNA polymerase sigma factor SigB -
MUA92_RS08315 (MUA92_08315) 1672927..1673409 - 483 WP_262559287.1 anti-sigma B factor RsbW -
MUA92_RS08320 (MUA92_08320) 1673411..1673737 - 327 WP_262559288.1 anti-sigma factor antagonist -
MUA92_RS08325 (MUA92_08325) 1673813..1674817 - 1005 WP_262559289.1 PP2C family protein-serine/threonine phosphatase -
MUA92_RS08330 (MUA92_08330) 1675103..1675456 - 354 WP_095117482.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA92_RS08335 (MUA92_08335) 1675457..1675627 - 171 WP_095117483.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA92_RS08340 (MUA92_08340) 1675716..1676864 - 1149 WP_262615434.1 alanine racemase -
MUA92_RS08345 (MUA92_08345) 1676892..1677251 - 360 WP_262559292.1 holo-ACP synthase -
MUA92_RS08350 (MUA92_08350) 1677248..1677811 - 564 WP_262559293.1 PH domain-containing protein -
MUA92_RS08355 (MUA92_08355) 1677801..1679306 - 1506 WP_262615435.1 PH domain-containing protein -
MUA92_RS08360 (MUA92_08360) 1679299..1679772 - 474 WP_262559295.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13030.17 Da        Isoelectric Point: 10.2682

>T240068 WP_095117482.1 NZ_CP094721:c1675456-1675103 [Staphylococcus sp. IVB6227]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIRT
VDKNRLKEKLTFLSDEKMKEVNNALGISLGLQVVQSR

Download         Length: 354 bp

>T240068 NZ_LS483486:c664763-664578 [Haemophilus influenzae]
ATGCGATCCAGCGACTTAATCAAGGAACTTAAAAGTGCAGGTTGTACTTTTGTCAGGCACGGTAAAGGCGATCATCAAAT
CTGGCAATCGCCCATCACAGGGAAGACGTTCCCAGTACCACACCCAAAACAACACGTATCCATCGGCACATTAAGATCCA
TTAAAAAATCGGCAGGGCTTCTATAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.02 Da        Isoelectric Point: 4.2313

>AT240068 WP_095117483.1 NZ_CP094721:c1675627-1675457 [Staphylococcus sp. IVB6227]
MSVFNQVKFKNLEQSLKEGYAQMADLNLSLATEAYSVECEACDCNESHLLSKHQDD

Download         Length: 171 bp

>AT240068 NZ_LS483486:c664547-664119 [Haemophilus influenzae]
ATGTTATTTACCATCGGCATTGAAACCCCAACAAATGAAAATGAAGCCTACGGCATTACGGTGCCAGCATTATTTACTGA
AGAATATTCCTGCTTTAGTGCCGCTGATACCCTTGAAGAAATCCCAACGCAGGCGACTGATGCCATTCATTCCATCTTAG
AAATAATGTTTGAAGACGGAATAGATATCAACGAACTTCAAGACAAAGGCTATCGTCACTACCAAACGCAAGAAGATTTC
AACTATTGCGATACTTGGTTGTTGCTTGATGTAGATATTTCCGCATATCAAGGCAAACGCCACCGTATTAATATCAGCTT
GCCTGAATACCTTATCAAACGTATTGATAGCCGTGTTGCAAGCAACCCCATTTACAAAGACCGCAGCCATTTTTTAGCAG
TTGCTTCACAAAAAGAGCTACGGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References