Detailed information of TA system TA240067

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1520957..1521733
• Replicon: chromosome
• Accession: NZ_CP094721
• Organism: Staphylococcus sp. IVB6227

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: MUA92_RS07465
• Protein ID: WP_262559135.1
• Coordinates: 1520957..1521115 (-)
• Length: 53 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: MUA92_RS07470
• Protein ID: WP_262559136.1
• Coordinates: 1521134..1521733 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA92_RS07450 (MUA92_07450)	1517192..1518718	-	1527	WP_262615407.1	exopolyphosphatase	-
MUA92_RS07455 (MUA92_07455)	1518740..1520125	-	1386	WP_262559133.1	class II fumarate hydratase	-
MUA92_RS07460 (MUA92_07460)	1520341..1520751	-	411	WP_262559134.1	hypothetical protein	-
MUA92_RS07465 (MUA92_07465)	1520957..1521115	-	159	WP_262559135.1	SAS053 family protein	Toxin
MUA92_RS07470 (MUA92_07470)	1521134..1521733	-	600	WP_262559136.1	glucosamine-6-phosphate isomerase	Antitoxin
MUA92_RS07475 (MUA92_07475)	1521757..1522935	-	1179	WP_262559137.1	N-acetylglucosamine-6-phosphate deacetylase	-
MUA92_RS07480 (MUA92_07480)	1522956..1523426	-	471	WP_262559138.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MUA92_RS07485 (MUA92_07485)	1523423..1524556	-	1134	WP_262559139.1	tRNA epoxyqueuosine(34) reductase QueG	-
MUA92_RS07490 (MUA92_07490)	1524715..1525437	-	723	WP_262559141.1	amino acid ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (132-195)

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 6185.56 Da
• Isoelectric Point: 3.9861

>T240067 WP_262559135.1 NZ_CP094721:c1521115-1520957 [Staphylococcus sp. IVB6227]
MNKQENEHGMVDSFEEVVELGKEMEQISEENDEQKFEQSHEEAVRSDRETDK

Nucleotide

• Length: 159 bp

>T240067 NZ_LS483486:576524-576802 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAAGAGGCTTATACAGA
CATTGGCGCAGTTTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATACCAACATGAATGAAGATATGGCGA
ATCTCTTTCAGGCAATGAATGCACTAAAACAGTTGGCGTGGATTTCTCAGTCGGTACGAGATATTCGCGCTTTTCGTATT
GAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22187.23 Da
• Isoelectric Point: 6.2339

>AT240067 WP_262559136.1 NZ_CP094721:c1521733-1521134 [Staphylococcus sp. IVB6227]
MAMNFKIFKDQGTAATFVADILRKQFNNNPTTIAGIHLKNDSVPVNAALQENVEKNPVDFSQIHILDYDKQTNYYKTLGV
PEKQIHEIPEDEKVESFIKHHAKTKENKGKLTLQVVTIDCDGNIGIPMNDGVLTAREVVLVLTGAEKAEVARKLYEENGS
TTFIPSSLKTHRMVNVVLDEAAAQGLPEDVRAYFTARYA

Nucleotide

• Length: 600 bp

>AT240067 NZ_LS483486:576324-576515 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTCGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGACATTTATCGCTTAT
CTTACCTACTTGAAGATCCCGAAGCTGAATAA