Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1520957..1521733 Replicon chromosome
Accession NZ_CP094721
Organism Staphylococcus sp. IVB6227

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag MUA92_RS07465 Protein ID WP_262559135.1
Coordinates 1520957..1521115 (-) Length 53 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag MUA92_RS07470 Protein ID WP_262559136.1
Coordinates 1521134..1521733 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA92_RS07450 (MUA92_07450) 1517192..1518718 - 1527 WP_262615407.1 exopolyphosphatase -
MUA92_RS07455 (MUA92_07455) 1518740..1520125 - 1386 WP_262559133.1 class II fumarate hydratase -
MUA92_RS07460 (MUA92_07460) 1520341..1520751 - 411 WP_262559134.1 hypothetical protein -
MUA92_RS07465 (MUA92_07465) 1520957..1521115 - 159 WP_262559135.1 SAS053 family protein Toxin
MUA92_RS07470 (MUA92_07470) 1521134..1521733 - 600 WP_262559136.1 glucosamine-6-phosphate isomerase Antitoxin
MUA92_RS07475 (MUA92_07475) 1521757..1522935 - 1179 WP_262559137.1 N-acetylglucosamine-6-phosphate deacetylase -
MUA92_RS07480 (MUA92_07480) 1522956..1523426 - 471 WP_262559138.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA92_RS07485 (MUA92_07485) 1523423..1524556 - 1134 WP_262559139.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA92_RS07490 (MUA92_07490) 1524715..1525437 - 723 WP_262559141.1 amino acid ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(132-195)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 6185.56 Da        Isoelectric Point: 3.9861

>T240067 WP_262559135.1 NZ_CP094721:c1521115-1520957 [Staphylococcus sp. IVB6227]
MNKQENEHGMVDSFEEVVELGKEMEQISEENDEQKFEQSHEEAVRSDRETDK

Download         Length: 159 bp

>T240067 NZ_LS483486:576524-576802 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAAGAGGCTTATACAGA
CATTGGCGCAGTTTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATACCAACATGAATGAAGATATGGCGA
ATCTCTTTCAGGCAATGAATGCACTAAAACAGTTGGCGTGGATTTCTCAGTCGGTACGAGATATTCGCGCTTTTCGTATT
GAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22187.23 Da        Isoelectric Point: 6.2339

>AT240067 WP_262559136.1 NZ_CP094721:c1521733-1521134 [Staphylococcus sp. IVB6227]
MAMNFKIFKDQGTAATFVADILRKQFNNNPTTIAGIHLKNDSVPVNAALQENVEKNPVDFSQIHILDYDKQTNYYKTLGV
PEKQIHEIPEDEKVESFIKHHAKTKENKGKLTLQVVTIDCDGNIGIPMNDGVLTAREVVLVLTGAEKAEVARKLYEENGS
TTFIPSSLKTHRMVNVVLDEAAAQGLPEDVRAYFTARYA

Download         Length: 600 bp

>AT240067 NZ_LS483486:576324-576515 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTCGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGACATTTATCGCTTAT
CTTACCTACTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References