240066

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) TsdAT/-
Location 1779107..1779629 Replicon chromosome
Accession NZ_CP094720
Organism Staphylococcus sp. IVB6233

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag MUA74_RS08890 Protein ID WP_262609113.1
Coordinates 1779107..1779328 (-) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag MUA74_RS08895 Protein ID WP_262603714.1
Coordinates 1779342..1779629 (-) Length 96 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA74_RS08870 (MUA74_08850) 1775108..1776313 + 1206 WP_262603710.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA74_RS08875 1776394..1776534 - 141 WP_262605150.1 Lmo0850 family protein -
MUA74_RS08880 (MUA74_08855) 1776620..1778800 - 2181 WP_262603711.1 heavy metal translocating P-type ATPase -
MUA74_RS08885 (MUA74_08860) 1778901..1779104 - 204 WP_262603712.1 cation transporter -
MUA74_RS08890 (MUA74_08865) 1779107..1779328 - 222 WP_262609113.1 heavy metal-associated domain-containing protein Toxin
MUA74_RS08895 (MUA74_08870) 1779342..1779629 - 288 WP_262603714.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA74_RS08900 (MUA74_08875) 1779773..1781263 + 1491 WP_262609114.1 cardiolipin synthase -
MUA74_RS08905 (MUA74_08880) 1781284..1781934 + 651 WP_262609115.1 HD domain-containing protein -
MUA74_RS08910 (MUA74_08885) 1781997..1782866 - 870 WP_262603717.1 membrane protein insertase YidC -
MUA74_RS08915 (MUA74_08890) 1782955..1783593 - 639 WP_262605151.1 thiamine phosphate synthase -
MUA74_RS08920 (MUA74_08895) 1783583..1784389 - 807 WP_262603718.1 hydroxyethylthiazole kinase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 74 a.a.        Molecular weight: 8299.26 Da        Isoelectric Point: 4.1813

>T240066 WP_262609113.1 NZ_CP094720:c1779328-1779107 [Staphylococcus sp. IVB6233]
VHSKVWLSGLSSEEQKQQLESRLRDMIGVETAEVDIDKQIVILTYETPANLNTLEKEIYDAGYPVINSYKGED

Download         Length: 222 bp

>T240066 NZ_LS483486:384848-385030 [Haemophilus influenzae]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAGTATCTGCTATCTCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAATCCAAACTGCCCAACAACGCTTAAGTGAATTAA
AAGAGAGATTGAAAAATGAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10929.52 Da        Isoelectric Point: 6.6368

>AT240066 WP_262603714.1 NZ_CP094720:c1779629-1779342 [Staphylococcus sp. IVB6233]
MIEHANHSEVTKRNLQSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVASKLLEHHMKGCILHKVEGGNEQE
AMDELLVTFQKLMKD

Download         Length: 288 bp

>AT240066 NZ_LS483486:385023-385319 [Haemophilus influenzae]
ATGAATAAAATTAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTACGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAGCTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References