Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1764823..1765347 Replicon chromosome
Accession NZ_CP094720
Organism Staphylococcus sp. IVB6233

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MUA74_RS08815 Protein ID WP_262603700.1
Coordinates 1764823..1765176 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MUA74_RS08820 Protein ID WP_095117483.1
Coordinates 1765177..1765347 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA74_RS08795 (MUA74_08775) 1761875..1762648 - 774 WP_262603697.1 RNA polymerase sigma factor SigB -
MUA74_RS08800 (MUA74_08780) 1762620..1763102 - 483 WP_262603698.1 anti-sigma B factor RsbW -
MUA74_RS08805 (MUA74_08785) 1763104..1763430 - 327 WP_262603699.1 anti-sigma factor antagonist -
MUA74_RS08810 (MUA74_08790) 1763507..1764478 - 972 WP_262605955.1 PP2C family protein-serine/threonine phosphatase -
MUA74_RS08815 (MUA74_08795) 1764823..1765176 - 354 WP_262603700.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA74_RS08820 (MUA74_08800) 1765177..1765347 - 171 WP_095117483.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA74_RS08825 (MUA74_08805) 1765436..1766584 - 1149 WP_262609109.1 alanine racemase -
MUA74_RS08830 (MUA74_08810) 1766638..1766988 - 351 WP_262603702.1 holo-ACP synthase -
MUA74_RS08835 (MUA74_08815) 1766991..1767560 - 570 WP_262609110.1 PH domain-containing protein -
MUA74_RS08840 (MUA74_08820) 1767535..1769049 - 1515 WP_262609111.1 PH domain-containing protein -
MUA74_RS08845 (MUA74_08825) 1769042..1769515 - 474 WP_262603705.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13072.25 Da        Isoelectric Point: 10.3952

>T240065 WP_262603700.1 NZ_CP094720:c1765176-1764823 [Staphylococcus sp. IVB6233]
MKRGDVYLADLSPVRGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIRT
VDKNRLKEKLTFLSEEKMKEVNNALGISLGLQVVQSR

Download         Length: 354 bp

>T240065 NZ_LS483486:c331268-330960 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTAAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCTATATTCAAGGCAATTTGGTACTGATTTACCAATACGTT
ATACGCGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.02 Da        Isoelectric Point: 4.2313

>AT240065 WP_095117483.1 NZ_CP094720:c1765347-1765177 [Staphylococcus sp. IVB6233]
MSVFNQVKFKNLEQSLKEGYAQMADLNLSLATEAYSVECEACDCNESHLLSKHQDD

Download         Length: 171 bp

>AT240065 NZ_LS483486:c331564-331268 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGCAAACAAAATCAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTATTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCTTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTTTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References