Detailed information of TA system TA240064

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1544262..1545038
• Replicon: chromosome
• Accession: NZ_CP094720
• Organism: Staphylococcus sp. IVB6233

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: MUA74_RS07485
• Protein ID: WP_262603510.1
• Coordinates: 1544262..1544420 (-)
• Length: 53 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: MUA74_RS07490
• Protein ID: WP_262603511.1
• Coordinates: 1544439..1545038 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA74_RS07470 (MUA74_07450)	1540376..1541902	-	1527	WP_262609017.1	exopolyphosphatase	-
MUA74_RS07475 (MUA74_07455)	1541924..1543309	-	1386	WP_262603508.1	class II fumarate hydratase	-
MUA74_RS07480 (MUA74_07460)	1543491..1543895	-	405	WP_262603509.1	hypothetical protein	-
MUA74_RS07485 (MUA74_07465)	1544262..1544420	-	159	WP_262603510.1	SAS053 family protein	Toxin
MUA74_RS07490 (MUA74_07470)	1544439..1545038	-	600	WP_262603511.1	glucosamine-6-phosphate isomerase	Antitoxin
MUA74_RS07495 (MUA74_07475)	1545065..1546237	-	1173	WP_262605317.1	N-acetylglucosamine-6-phosphate deacetylase	-
MUA74_RS07500 (MUA74_07480)	1546258..1546728	-	471	WP_262605318.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MUA74_RS07505 (MUA74_07485)	1546728..1547858	-	1131	WP_262609574.1	tRNA epoxyqueuosine(34) reductase QueG	-
MUA74_RS07510 (MUA74_07490)	1548074..1548796	-	723	WP_262603514.1	amino acid ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (131-195)

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 6189.45 Da
• Isoelectric Point: 3.8145

>T240064 WP_262603510.1 NZ_CP094720:c1544420-1544262 [Staphylococcus sp. IVB6233]
MNKQENEHGMVDSFDEVVELGKEMEQISEENDEEKYEQSHEEAVRSDRETDE

Nucleotide

• Length: 159 bp

>T240064 NZ_LS483486:46735-47133 [Haemophilus influenzae]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCTGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGCTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22037.03 Da
• Isoelectric Point: 5.6098

>AT240064 WP_262603511.1 NZ_CP094720:c1545038-1544439 [Staphylococcus sp. IVB6233]
MAMNFKIFKDQNTAATFVADILRKQFSNNPTTIAGIHLKNDDAPVNGALQINVENNPVDFSQIHILDYDKNDAYFKALGV
PEKQIHEIPEDEKVEAFIKHHAKTKENKGKLTLQVVTIDTDGSIGIPMNDAVLTAREIVLVLTGAEKAEVVRKLYEENGS
TTFVPSSLKSHRMVNVVLDEAAAQGLPEDVRAYFSARFA

Nucleotide

• Length: 600 bp

>AT240064 NZ_LS483486:46502-46735 [Haemophilus influenzae]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG