Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1742463..1742985 Replicon chromosome
Accession NZ_CP094719
Organism Staphylococcus sp. IVB6238

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag MUA48_RS08805 Protein ID WP_262603713.1
Coordinates 1742463..1742684 (-) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag MUA48_RS08810 Protein ID WP_262603714.1
Coordinates 1742698..1742985 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA48_RS08785 (MUA48_08760) 1738464..1739669 + 1206 WP_262603710.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA48_RS08790 (MUA48_08765) 1739750..1739890 - 141 WP_262605150.1 Lmo0850 family protein -
MUA48_RS08795 (MUA48_08770) 1739976..1742156 - 2181 WP_262603711.1 heavy metal translocating P-type ATPase -
MUA48_RS08800 (MUA48_08775) 1742257..1742460 - 204 WP_262603712.1 cation transporter -
MUA48_RS08805 (MUA48_08780) 1742463..1742684 - 222 WP_262603713.1 heavy metal-associated domain-containing protein Toxin
MUA48_RS08810 (MUA48_08785) 1742698..1742985 - 288 WP_262603714.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA48_RS08815 (MUA48_08790) 1743129..1744619 + 1491 WP_262603715.1 cardiolipin synthase -
MUA48_RS08820 (MUA48_08795) 1744640..1745290 + 651 WP_262603716.1 HD domain-containing protein -
MUA48_RS08825 (MUA48_08800) 1745353..1746222 - 870 WP_262603717.1 membrane protein insertase YidC -
MUA48_RS08830 (MUA48_08805) 1746311..1746949 - 639 WP_262605151.1 thiamine phosphate synthase -
MUA48_RS08835 (MUA48_08810) 1746939..1747745 - 807 WP_262603718.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(20-65)

Antitoxin

Metal-sensitive transcriptional repressor

(12-90)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8298.28 Da        Isoelectric Point: 4.2694

>T240063 WP_262603713.1 NZ_CP094719:c1742684-1742463 [Staphylococcus sp. IVB6238]
VHSKVWLSGLSSEEQKQQLESRLRDMIGVETAEVDINKQIVILTYETPANLNTLEKEIYDAGYPVINSYKGED

Download         Length: 222 bp

>T240063 NZ_LS483485:c1142574-1141294 [Aggregatibacter aphrophilus]
ATGAGCAACTCGATTCTAAACGTTGCCATGAATGGCTTGTTAGTCGGTGAATGGCGAAAACTCACCAGTGGTGCAAGTGA
ATTTCAATACGCTGAAAAATGGTTGGAGTCTGTGCGTTCGCGCCCTATTTCATTGTCACTGCCCTTGTCACACAAAATTT
ATCGAGGAGATTCCGTTTACAATTTCTTCGATAATCTCCTCCCGGACAATGAGCAGATCCGCTCACGCATTCAACAACGT
TTCCAAACCTCAACGAAATCCCCATTTGATTTACTTTCGGCGATTGGACAGGATTGTATCGGCGCAATTCAACTTTATCA
GGGCGAGAACCGCTCGGTACGTCAAATTTATGCAGAACCGCTAAATGACAAAGAGGTGGAAAACGTGCTGAGAAACTACC
GCACTTTTCCTCTCGGCATGGAAGAAAGCGAGGATTTCCGAATTTCTTTAGCCGGTGCTCAGGAAAAAACAGCGCTGCTT
TATTATCAGAATCAATGGCAGCGCCCTTTGCATTCCACCGCGACCAGCCATATTTTTAAACTCCCGATTGGTATGGTGGC
ACAAGGGCAACTTGATCTTTGCGGTAGCTGTGAAAATGAATGGCTTTGCTTGAATATTATGAAAGCCTTCGGTTTGCCGG
TTCCTCGAAGCCAAATTCAGTATTTCGGTGAAATGAAAGTGCTGATAGTGGAACGCTTTGATCGCCGTTGGTCTGAAAAT
AGAAGTTGGCTAATTCGTTTACCACAGGAAGATATGTGCCAAGCACTCAACATCGCCCCTGCGCGAAAATATGAAAATGA
CGGCGGGCCGAGCATTCTTCAAATTATGTCACTTCTCAACGGTTCATCCAACGCCCAAGCAGATCGCAAGCAGTTTTTTA
AAGCGCAAATTATTTTTTGGTTACTTTGTGCCATTGACGGCCATGGCAAAAATTTCAGTTTGTTTTTAGAACAAGAGAAT
CGCTATCGTCTAACGCCTTTTTATGACGTGATGTCCGCCTATCCGCTCATCAAACACAACGGACTACAAAAGCAAAAAGT
CAAAATGGCCATGGCGTGGCACGGCGAAAATAAACATTATTTATGGGATAAAATACAACCCCGCCACATTTTCAACACCG
CTAAACTCGCAGGCTTGGCAAAGGAAACAGTTGAAGACGTTTTGCATGAGATCAGTGCGCTATATCCAAGAGTCAGTGAA
ATAAATACCCATGGATTGCCTGATGAAATTGTCGAGCCAATTTTAATGGGATTGGAAATGCAGATGAAAAAGATAAGTTA
A

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10929.52 Da        Isoelectric Point: 6.6368

>AT240063 WP_262603714.1 NZ_CP094719:c1742985-1742698 [Staphylococcus sp. IVB6238]
MIEHANHSEVTKRNLQSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVASKLLEHHMKGCILHKVEGGNEQE
AMDELLVTFQKLMKD

Download         Length: 288 bp

>AT240063 NZ_LS483485:c1142852-1142574 [Aggregatibacter aphrophilus]
ATGGTTATCACCACCGCAAAAATGCTTTCTCATGTCATTCGGGAATTTCGCTATCAAGGCGATCTGTCACAAACTGATGT
TGCTAAACTCGCCGGAACGACCCAAGCTAGAATTTCAGCGTTTGAGAATGAGCCGGAGCGTACTAAGTTAGAAACGCTGT
TTAAGATTTTGGCAGGATTAGAGCTAGAGCTGATTGTACAACCTCGCAAAAAATCATCTGATACTGCCCTTTCAATTAAA
GAACCAGCAGCAACATACGATGACGATGAGGCATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References