Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1728179..1728703 Replicon chromosome
Accession NZ_CP094719
Organism Staphylococcus sp. IVB6238

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MUA48_RS08730 Protein ID WP_262603700.1
Coordinates 1728179..1728532 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MUA48_RS08735 Protein ID WP_095117483.1
Coordinates 1728533..1728703 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA48_RS08710 (MUA48_08685) 1725231..1726004 - 774 WP_262603697.1 RNA polymerase sigma factor SigB -
MUA48_RS08715 (MUA48_08690) 1725976..1726458 - 483 WP_262603698.1 anti-sigma B factor RsbW -
MUA48_RS08720 (MUA48_08695) 1726460..1726786 - 327 WP_262603699.1 anti-sigma factor antagonist -
MUA48_RS08725 (MUA48_08700) 1726863..1727834 - 972 WP_262605149.1 PP2C family protein-serine/threonine phosphatase -
MUA48_RS08730 (MUA48_08705) 1728179..1728532 - 354 WP_262603700.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA48_RS08735 (MUA48_08710) 1728533..1728703 - 171 WP_095117483.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA48_RS08740 (MUA48_08715) 1728792..1729940 - 1149 WP_262603701.1 alanine racemase -
MUA48_RS08745 (MUA48_08720) 1729994..1730344 - 351 WP_262603702.1 holo-ACP synthase -
MUA48_RS08750 (MUA48_08725) 1730347..1730916 - 570 WP_262603703.1 PH domain-containing protein -
MUA48_RS08755 (MUA48_08730) 1730891..1732405 - 1515 WP_262603704.1 PH domain-containing protein -
MUA48_RS08760 (MUA48_08735) 1732398..1732871 - 474 WP_262603705.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13072.25 Da        Isoelectric Point: 10.3952

>T240062 WP_262603700.1 NZ_CP094719:c1728532-1728179 [Staphylococcus sp. IVB6238]
MKRGDVYLADLSPVRGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIRT
VDKNRLKEKLTFLSEEKMKEVNNALGISLGLQVVQSR

Download         Length: 354 bp

>T240062 NZ_LS483485:559450-559788 [Aggregatibacter aphrophilus]
GTGAAACTATCGTTTATTGAATTGCCGCCCTTTGAGCGTTACAGAAAAGCGTATTTGTCCGATGATGAATATAGGGCTTT
CCAGAATGAGCTATTAGAAAACCCCGAAAAGGGAGACGTGATACAGAACACGGGCGGATTGAGAAAAATTAGAATCGCTG
ACAGTGAGAGAAACAAAGGTAAACGTGGTGGCGCACGAGTGATTTATTACTATCTCATACGTAAATCACGGATATTACTC
GTTACTGCTTACAGTAAAAACAGATGCGAAGATTTAACCACAGAGCAATATAAAATTTTAGCTAAACTGGTGAAAGAGAT
AGAGGAGCTAGAGCAATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.02 Da        Isoelectric Point: 4.2313

>AT240062 WP_095117483.1 NZ_CP094719:c1728703-1728533 [Staphylococcus sp. IVB6238]
MSVFNQVKFKNLEQSLKEGYAQMADLNLSLATEAYSVECEACDCNESHLLSKHQDD

Download         Length: 171 bp

>AT240062 NZ_LS483485:559785-560093 [Aggregatibacter aphrophilus]
ATGAGTGAATTATTTGATGAGCTTATAGAGGGGCTAAATGCCTATAAAGACTTTACACAGGGGAAAATAACGCTAAGAGT
AGAGACGCGTGAACGAATTGAACCTGCAAGCATTACGGCAGAGGAAGTGAAAGCAATTAGAGAGAAATTAAACCTTTCTC
AAGCTGTCTTTGCGCAGAAGTTACGAACCAGTGTAAGAACCTATCAAGGCTGGGAGCAAGGCAAAACCAAACCTAGCGCG
CACGCCTCTTTATTGTTGCGCATGGTGGATAAAGCCCCGCAAACCTTTGAGCTTATCGCAGGGATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References