Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1514756..1515532 Replicon chromosome
Accession NZ_CP094719
Organism Staphylococcus sp. IVB6238

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag MUA48_RS07440 Protein ID WP_262603510.1
Coordinates 1514756..1514914 (-) Length 53 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag MUA48_RS07445 Protein ID WP_262603511.1
Coordinates 1514933..1515532 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA48_RS07425 (MUA48_07395) 1510870..1512396 - 1527 WP_262603507.1 exopolyphosphatase -
MUA48_RS07430 (MUA48_07400) 1512418..1513803 - 1386 WP_262603508.1 class II fumarate hydratase -
MUA48_RS07435 (MUA48_07405) 1513985..1514389 - 405 WP_262603509.1 hypothetical protein -
MUA48_RS07440 (MUA48_07410) 1514756..1514914 - 159 WP_262603510.1 SAS053 family protein Toxin
MUA48_RS07445 (MUA48_07415) 1514933..1515532 - 600 WP_262603511.1 glucosamine-6-phosphate isomerase Antitoxin
MUA48_RS07450 (MUA48_07420) 1515559..1516731 - 1173 WP_262603512.1 N-acetylglucosamine-6-phosphate deacetylase -
MUA48_RS07455 (MUA48_07425) 1516752..1517222 - 471 WP_262603513.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA48_RS07460 (MUA48_07430) 1517222..1518352 - 1131 WP_262605141.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA48_RS07465 (MUA48_07435) 1518568..1519290 - 723 WP_262603514.1 amino acid ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(131-195)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 6189.45 Da        Isoelectric Point: 3.8145

>T240061 WP_262603510.1 NZ_CP094719:c1514914-1514756 [Staphylococcus sp. IVB6238]
MNKQENEHGMVDSFDEVVELGKEMEQISEENDEEKYEQSHEEAVRSDRETDE

Download         Length: 159 bp

>T240061 NZ_LS483484:c2596121-2596014 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22037.03 Da        Isoelectric Point: 5.6098

>AT240061 WP_262603511.1 NZ_CP094719:c1515532-1514933 [Staphylococcus sp. IVB6238]
MAMNFKIFKDQNTAATFVADILRKQFSNNPTTIAGIHLKNDDAPVNGALQINVENNPVDFSQIHILDYDKNDAYFKALGV
PEKQIHEIPEDEKVEAFIKHHAKTKENKGKLTLQVVTIDTDGSIGIPMNDAVLTAREIVLVLTGAEKAEVVRKLYEENGS
TTFVPSSLKSHRMVNVVLDEAAAQGLPEDVRAYFSARFA

Download         Length: 600 bp

>AT240061 NZ_LS483484:2595937-2595997 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References