Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 817940..818743 Replicon chromosome
Accession NZ_CP094719
Organism Staphylococcus sp. IVB6238

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA48_RS04065 Protein ID WP_262604814.1
Coordinates 817940..818401 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA48_RS04070 Protein ID WP_262604815.1
Coordinates 818414..818743 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA48_RS04040 (MUA48_04010) 813240..813893 - 654 WP_262604809.1 CPBP family intramembrane metalloprotease -
MUA48_RS04045 (MUA48_04015) 814171..815139 - 969 WP_262604810.1 DNA cytosine methyltransferase -
MUA48_RS04050 (MUA48_04020) 815203..815730 - 528 WP_262604811.1 Bsp6I family type II restriction endonuclease -
MUA48_RS04055 (MUA48_04025) 815912..816529 + 618 WP_262604812.1 hypothetical protein -
MUA48_RS04060 (MUA48_04030) 817000..817899 - 900 WP_262604813.1 HIRAN domain-containing protein -
MUA48_RS04065 (MUA48_04035) 817940..818401 - 462 WP_262604814.1 ImmA/IrrE family metallo-endopeptidase Toxin
MUA48_RS04070 (MUA48_04040) 818414..818743 - 330 WP_262604815.1 helix-turn-helix transcriptional regulator Antitoxin
MUA48_RS04075 (MUA48_04045) 818935..819180 + 246 WP_096543105.1 helix-turn-helix transcriptional regulator -
MUA48_RS04080 (MUA48_04050) 819195..819950 + 756 WP_262604816.1 phage antirepressor KilAC domain-containing protein -
MUA48_RS04085 (MUA48_04055) 820059..820337 - 279 WP_202430073.1 hypothetical protein -
MUA48_RS04090 (MUA48_04060) 820478..820744 + 267 WP_262604817.1 hypothetical protein -
MUA48_RS04095 (MUA48_04065) 820767..821306 - 540 WP_262604818.1 hypothetical protein -
MUA48_RS04100 (MUA48_04070) 821396..821536 + 141 WP_262604819.1 hypothetical protein -
MUA48_RS04105 (MUA48_04075) 821529..821738 - 210 WP_262604820.1 hypothetical protein -
MUA48_RS04110 (MUA48_04080) 821805..822128 + 324 WP_262604821.1 DUF771 domain-containing protein -
MUA48_RS04115 (MUA48_04085) 822384..822527 + 144 WP_262604822.1 hypothetical protein -
MUA48_RS04120 (MUA48_04090) 822529..823011 + 483 WP_262604823.1 siphovirus Gp157 family protein -
MUA48_RS04125 (MUA48_04095) 823011..823682 + 672 WP_262604824.1 ERF family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 807283..854702 47419


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(17-116)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18136.70 Da        Isoelectric Point: 5.9343

>T240060 WP_262604814.1 NZ_CP094719:c818401-817940 [Staphylococcus sp. IVB6238]
MGLYEETLIQHDYIDVREANVLPDDLDGVWLGDLILIKRNLPEKKKVEVLFEELAHHKLTYGDITNQKQFNNRKFENYAR
RYSYEKSMPLSGIVQAFEQGVHNLYELANFFEISEGHVLDCIEHYKKKYGLQVKYGKYLIRFEPLTIYKDLAD

Download         Length: 462 bp

>T240060 NZ_LS483484:c2570905-2570639 [Staphylococcus aureus]
ATGGTTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTAATTAAAAGTATTGACAGAAATGGTGCGTTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12712.40 Da        Isoelectric Point: 9.3985

>AT240060 WP_262604815.1 NZ_CP094719:c818743-818414 [Staphylococcus sp. IVB6238]
MRNNDEIITIIKASMKKQNLSLSELARRVGVAKSAVSRYLNLTREFPLNRAEDFAKALSISTEYLLGFEKSEQKQEQPQH
RAAHLEGELTDEEWQRVLDYADYIRSKRK

Download         Length: 330 bp

>AT240060 NZ_LS483484:c2571156-2570905 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATAGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTGTAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References