Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1099489..1099981 Replicon chromosome
Accession NC_012926
Organism Streptococcus suis BM407

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag SSUBM407_RS05415 Protein ID WP_011922404.1
Coordinates 1099724..1099981 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag SSUBM407_RS05410 Protein ID WP_012775104.1
Coordinates 1099489..1099740 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSUBM407_RS05390 1095056..1095802 + 747 WP_011922411.1 ABC transporter permease -
SSUBM407_RS05395 1095804..1096538 + 735 WP_011922410.1 ABC transporter permease -
SSUBM407_RS05400 1096674..1097426 + 753 WP_011922409.1 ABC transporter ATP-binding protein -
SSUBM407_RS05405 1097427..1099397 + 1971 WP_012775105.1 FtsX-like permease family protein -
SSUBM407_RS05410 1099489..1099740 + 252 WP_012775104.1 hypothetical protein Antitoxin
SSUBM407_RS05415 1099724..1099981 + 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSUBM407_RS05420 1100020..1100685 + 666 WP_012775103.1 response regulator transcription factor -
SSUBM407_RS05425 1100682..1101623 + 942 WP_012775102.1 sensor histidine kinase -
SSUBM407_RS05430 1101699..1103207 + 1509 WP_011922400.1 phosphomannomutase/phosphoglucomutase -
SSUBM407_RS05435 1103277..1104347 - 1071 WP_012775101.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(O) / ant(6)-Ia / tet(M) / tet(L) - 1032547..1125755 93208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T24006 WP_011922404.1 NC_012926:1099724-1099981 [Streptococcus suis BM407]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T24006 NC_012926:1099724-1099981 [Streptococcus suis BM407]
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACTTGTCCAGTCATGTGACTGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT24006 WP_012775104.1 NC_012926:1099489-1099740 [Streptococcus suis BM407]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp

>AT24006 NC_012926:1099489-1099740 [Streptococcus suis BM407]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCTCTCGAAGATGAATATGATGCCCGTGTGGCAGATATCGCTCTGTCTG
AATACGAGGCAGACTTGGCGAAAGGCATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References