Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) TsdAT/-
Location 1676093..1676615 Replicon chromosome
Accession NZ_CP094718
Organism Staphylococcus sp. IVB6240

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag MUA88_RS08320 Protein ID WP_262605385.1
Coordinates 1676093..1676314 (-) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag MUA88_RS08325 Protein ID WP_262603714.1
Coordinates 1676328..1676615 (-) Length 96 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA88_RS08300 (MUA88_08285) 1672094..1673299 + 1206 WP_262603710.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA88_RS08305 1673380..1673520 - 141 WP_262605150.1 Lmo0850 family protein -
MUA88_RS08310 (MUA88_08290) 1673606..1675786 - 2181 WP_262605384.1 heavy metal translocating P-type ATPase -
MUA88_RS08315 (MUA88_08295) 1675887..1676090 - 204 WP_262603712.1 cation transporter -
MUA88_RS08320 (MUA88_08300) 1676093..1676314 - 222 WP_262605385.1 heavy metal-associated domain-containing protein Toxin
MUA88_RS08325 (MUA88_08305) 1676328..1676615 - 288 WP_262603714.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA88_RS08330 (MUA88_08310) 1676759..1678249 + 1491 WP_262605386.1 cardiolipin synthase -
MUA88_RS08335 (MUA88_08315) 1678270..1678920 + 651 WP_262605387.1 HD domain-containing protein -
MUA88_RS08340 (MUA88_08320) 1678983..1679852 - 870 WP_262603717.1 membrane protein insertase YidC -
MUA88_RS08345 (MUA88_08325) 1679941..1680579 - 639 WP_262605151.1 thiamine phosphate synthase -
MUA88_RS08350 (MUA88_08330) 1680569..1681375 - 807 WP_262605388.1 hydroxyethylthiazole kinase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 74 a.a.        Molecular weight: 8303.25 Da        Isoelectric Point: 4.1813

>T240059 WP_262605385.1 NZ_CP094718:c1676314-1676093 [Staphylococcus sp. IVB6240]
VHSKVWLSGLSSEEQKQQLESRLRDMIGVETAEVDIDKQIVILTYETPANLNTLEKEIYDAGYTVINSYKGED

Download         Length: 222 bp

>T240059 NZ_LS483484:c2305686-2305582 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGATTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10929.52 Da        Isoelectric Point: 6.6368

>AT240059 WP_262603714.1 NZ_CP094718:c1676615-1676328 [Staphylococcus sp. IVB6240]
MIEHANHSEVTKRNLQSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVASKLLEHHMKGCILHKVEGGNEQE
AMDELLVTFQKLMKD

Download         Length: 288 bp

>AT240059 NZ_LS483484:2305489-2305527 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References