Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1661809..1662333 Replicon chromosome
Accession NZ_CP094718
Organism Staphylococcus sp. IVB6240

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MUA88_RS08245 Protein ID WP_262603700.1
Coordinates 1661809..1662162 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MUA88_RS08250 Protein ID WP_095117483.1
Coordinates 1662163..1662333 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA88_RS08225 (MUA88_08210) 1658861..1659634 - 774 WP_262603697.1 RNA polymerase sigma factor SigB -
MUA88_RS08230 (MUA88_08215) 1659606..1660088 - 483 WP_262603698.1 anti-sigma B factor RsbW -
MUA88_RS08235 (MUA88_08220) 1660090..1660416 - 327 WP_262603699.1 anti-sigma factor antagonist -
MUA88_RS08240 (MUA88_08225) 1660493..1661464 - 972 WP_262605955.1 PP2C family protein-serine/threonine phosphatase -
MUA88_RS08245 (MUA88_08230) 1661809..1662162 - 354 WP_262603700.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA88_RS08250 (MUA88_08235) 1662163..1662333 - 171 WP_095117483.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA88_RS08255 (MUA88_08240) 1662422..1663570 - 1149 WP_262605380.1 alanine racemase -
MUA88_RS08260 (MUA88_08245) 1663624..1663974 - 351 WP_262603702.1 holo-ACP synthase -
MUA88_RS08265 (MUA88_08250) 1663977..1664546 - 570 WP_262603703.1 PH domain-containing protein -
MUA88_RS08270 (MUA88_08255) 1664521..1666035 - 1515 WP_262603704.1 PH domain-containing protein -
MUA88_RS08275 (MUA88_08260) 1666028..1666501 - 474 WP_262605381.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13072.25 Da        Isoelectric Point: 10.3952

>T240058 WP_262603700.1 NZ_CP094718:c1662162-1661809 [Staphylococcus sp. IVB6240]
MKRGDVYLADLSPVRGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIRT
VDKNRLKEKLTFLSEEKMKEVNNALGISLGLQVVQSR

Download         Length: 354 bp

>T240058 NZ_LS483484:c2246219-2246010 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.02 Da        Isoelectric Point: 4.2313

>AT240058 WP_095117483.1 NZ_CP094718:c1662333-1662163 [Staphylococcus sp. IVB6240]
MSVFNQVKFKNLEQSLKEGYAQMADLNLSLATEAYSVECEACDCNESHLLSKHQDD

Download         Length: 171 bp

>AT240058 NZ_LS483484:c2246524-2246231 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References