Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1482876..1483652 Replicon chromosome
Accession NZ_CP094718
Organism Staphylococcus sp. IVB6240

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag MUA88_RS07250 Protein ID WP_262603510.1
Coordinates 1482876..1483034 (-) Length 53 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag MUA88_RS07255 Protein ID WP_262603511.1
Coordinates 1483053..1483652 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA88_RS07235 (MUA88_07220) 1478990..1480516 - 1527 WP_262605316.1 exopolyphosphatase -
MUA88_RS07240 (MUA88_07225) 1480538..1481923 - 1386 WP_262603508.1 class II fumarate hydratase -
MUA88_RS07245 (MUA88_07230) 1482105..1482509 - 405 WP_262603509.1 hypothetical protein -
MUA88_RS07250 (MUA88_07235) 1482876..1483034 - 159 WP_262603510.1 SAS053 family protein Toxin
MUA88_RS07255 (MUA88_07240) 1483053..1483652 - 600 WP_262603511.1 glucosamine-6-phosphate isomerase Antitoxin
MUA88_RS07260 (MUA88_07245) 1483679..1484851 - 1173 WP_262605317.1 N-acetylglucosamine-6-phosphate deacetylase -
MUA88_RS07265 (MUA88_07250) 1484872..1485342 - 471 WP_262605318.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA88_RS07270 (MUA88_07255) 1485342..1486472 - 1131 WP_262605952.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA88_RS07275 (MUA88_07260) 1486688..1487410 - 723 WP_262603514.1 amino acid ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(131-195)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 6189.45 Da        Isoelectric Point: 3.8145

>T240057 WP_262603510.1 NZ_CP094718:c1483034-1482876 [Staphylococcus sp. IVB6240]
MNKQENEHGMVDSFDEVVELGKEMEQISEENDEEKYEQSHEEAVRSDRETDE

Download         Length: 159 bp

>T240057 NZ_LS483484:c2225636-2225274 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACATACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGTTCATCAGAAAAATTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22037.03 Da        Isoelectric Point: 5.6098

>AT240057 WP_262603511.1 NZ_CP094718:c1483652-1483053 [Staphylococcus sp. IVB6240]
MAMNFKIFKDQNTAATFVADILRKQFSNNPTTIAGIHLKNDDAPVNGALQINVENNPVDFSQIHILDYDKNDAYFKALGV
PEKQIHEIPEDEKVEAFIKHHAKTKENKGKLTLQVVTIDTDGSIGIPMNDAVLTAREIVLVLTGAEKAEVVRKLYEENGS
TTFVPSSLKSHRMVNVVLDEAAAQGLPEDVRAYFSARFA

Download         Length: 600 bp

>AT240057 NZ_LS483484:c2225803-2225633 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References