Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1639609..1640133 Replicon chromosome
Accession NZ_CP094717
Organism Staphylococcus sp. IVB6246

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MUA26_RS08200 Protein ID WP_262603700.1
Coordinates 1639609..1639962 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MUA26_RS08205 Protein ID WP_095117483.1
Coordinates 1639963..1640133 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA26_RS08180 (MUA26_08160) 1636661..1637434 - 774 WP_262613969.1 RNA polymerase sigma factor SigB -
MUA26_RS08185 (MUA26_08165) 1637406..1637888 - 483 WP_262613970.1 anti-sigma B factor RsbW -
MUA26_RS08190 (MUA26_08170) 1637890..1638216 - 327 WP_262613971.1 anti-sigma factor antagonist -
MUA26_RS08195 (MUA26_08175) 1638293..1639264 - 972 WP_262614707.1 PP2C family protein-serine/threonine phosphatase -
MUA26_RS08200 (MUA26_08180) 1639609..1639962 - 354 WP_262603700.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA26_RS08205 (MUA26_08185) 1639963..1640133 - 171 WP_095117483.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA26_RS08210 (MUA26_08190) 1640222..1641370 - 1149 WP_262613972.1 alanine racemase -
MUA26_RS08215 (MUA26_08195) 1641424..1641774 - 351 WP_262613973.1 holo-ACP synthase -
MUA26_RS08220 (MUA26_08200) 1641777..1642346 - 570 WP_262603703.1 PH domain-containing protein -
MUA26_RS08225 (MUA26_08205) 1642321..1643835 - 1515 WP_262603704.1 PH domain-containing protein -
MUA26_RS08230 (MUA26_08210) 1643828..1644301 - 474 WP_262603705.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13072.25 Da        Isoelectric Point: 10.3952

>T240054 WP_262603700.1 NZ_CP094717:c1639962-1639609 [Staphylococcus sp. IVB6246]
MKRGDVYLADLSPVRGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIRT
VDKNRLKEKLTFLSEEKMKEVNNALGISLGLQVVQSR

Download         Length: 354 bp

>T240054 NZ_LS483484:c2026764-2026612 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.02 Da        Isoelectric Point: 4.2313

>AT240054 WP_095117483.1 NZ_CP094717:c1640133-1639963 [Staphylococcus sp. IVB6246]
MSVFNQVKFKNLEQSLKEGYAQMADLNLSLATEAYSVECEACDCNESHLLSKHQDD

Download         Length: 171 bp

>AT240054 NZ_LS483484:c2027388-2026789 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTTGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
CGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References