Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1527419..1528216 Replicon chromosome
Accession NZ_CP094717
Organism Staphylococcus sp. IVB6246

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA26_RS07620 Protein ID WP_262613901.1
Coordinates 1527761..1528216 (+) Length 152 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA26_RS07615 Protein ID WP_262613899.1
Coordinates 1527419..1527748 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA26_RS07555 (MUA26_07535) 1522626..1523042 - 417 WP_262613885.1 single-stranded DNA-binding protein -
MUA26_RS07560 (MUA26_07540) 1523042..1523713 - 672 WP_262613887.1 ERF family protein -
MUA26_RS07565 (MUA26_07545) 1523713..1524195 - 483 WP_262613889.1 siphovirus Gp157 family protein -
MUA26_RS07570 (MUA26_07550) 1524188..1524340 - 153 WP_262613890.1 hypothetical protein -
MUA26_RS07575 (MUA26_07555) 1524519..1524686 - 168 WP_262603601.1 hypothetical protein -
MUA26_RS07580 (MUA26_07560) 1524833..1525003 + 171 WP_262603602.1 hypothetical protein -
MUA26_RS07585 (MUA26_07565) 1525015..1525305 - 291 WP_262603603.1 hypothetical protein -
MUA26_RS07590 (MUA26_07570) 1525365..1525595 + 231 WP_262613891.1 hypothetical protein -
MUA26_RS07595 (MUA26_07575) 1525570..1525746 - 177 WP_262613893.1 hypothetical protein -
MUA26_RS07600 (MUA26_07580) 1525760..1526203 - 444 WP_262613895.1 hypothetical protein -
MUA26_RS07605 (MUA26_07585) 1526218..1526967 - 750 WP_262613896.1 phage antirepressor KilAC domain-containing protein -
MUA26_RS07610 (MUA26_07590) 1526982..1527227 - 246 WP_262613898.1 helix-turn-helix transcriptional regulator -
MUA26_RS07615 (MUA26_07595) 1527419..1527748 + 330 WP_262613899.1 helix-turn-helix transcriptional regulator Antitoxin
MUA26_RS07620 (MUA26_07600) 1527761..1528216 + 456 WP_262613901.1 ImmA/IrrE family metallo-endopeptidase Toxin
MUA26_RS07625 (MUA26_07605) 1528233..1529027 + 795 WP_262613902.1 hypothetical protein -
MUA26_RS07630 (MUA26_07610) 1528999..1530120 + 1122 WP_262613904.1 YdcF family protein -
MUA26_RS07635 (MUA26_07615) 1530163..1530393 + 231 WP_262603608.1 hypothetical protein -
MUA26_RS07640 (MUA26_07620) 1530469..1531863 + 1395 WP_262613906.1 recombinase family protein -
MUA26_RS07645 (MUA26_07625) 1531878..1532762 - 885 Protein_1462 PTS transporter subunit EIIC -
MUA26_RS07650 (MUA26_07630) 1532762..1533079 - 318 WP_262603623.1 lactose-specific PTS transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1517217..1531863 14646


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(31-116)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-65)


Sequences

Toxin        


Download         Length: 152 a.a.        Molecular weight: 17892.44 Da        Isoelectric Point: 6.4942

>T240053 WP_262613901.1 NZ_CP094717:1527761-1528216 [Staphylococcus sp. IVB6246]
MGLYEETLIQHDYIEVRETNVLPDDLDGAWLGDLILIKRHLPEKKKVEVLFEELAHHKLTYGDITNQKQFNNRKFENYAR
RYSYETSVPLSGIVEAFKQGVRNLYELANFFEITEGHVLDCIAHYKKKYGLQVRYGEYLIRFEPLTIYKSV

Download         Length: 456 bp

>T240053 NZ_LS483484:1972161-1972256 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12740.42 Da        Isoelectric Point: 9.4170

>AT240053 WP_262613899.1 NZ_CP094717:1527419-1527748 [Staphylococcus sp. IVB6246]
MRNNDEIITIIKASMKKQNLSLSELARRVGVAKSAVSRYLNLTREFPLNRAEDFAKALSISTEYLLGFEKSEQKQEQPQH
RAAHLEGELTDEEWQRVLDYADYIRSRRK

Download         Length: 330 bp

>AT240053 NZ_LS483484:c1972341-1972284 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References