Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1468477..1469253 Replicon chromosome
Accession NZ_CP094717
Organism Staphylococcus sp. IVB6246

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag MUA26_RS07170 Protein ID WP_262603510.1
Coordinates 1468477..1468635 (-) Length 53 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag MUA26_RS07175 Protein ID WP_262603511.1
Coordinates 1468654..1469253 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA26_RS07155 (MUA26_07135) 1464591..1466117 - 1527 WP_262613850.1 exopolyphosphatase -
MUA26_RS07160 (MUA26_07140) 1466139..1467524 - 1386 WP_262613851.1 class II fumarate hydratase -
MUA26_RS07165 (MUA26_07145) 1467706..1468110 - 405 WP_262603509.1 hypothetical protein -
MUA26_RS07170 (MUA26_07150) 1468477..1468635 - 159 WP_262603510.1 SAS053 family protein Toxin
MUA26_RS07175 (MUA26_07155) 1468654..1469253 - 600 WP_262603511.1 glucosamine-6-phosphate isomerase Antitoxin
MUA26_RS07180 (MUA26_07160) 1469280..1470452 - 1173 WP_262613853.1 N-acetylglucosamine-6-phosphate deacetylase -
MUA26_RS07185 (MUA26_07165) 1470473..1470943 - 471 WP_262613855.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA26_RS07190 (MUA26_07170) 1470943..1472073 - 1131 WP_262614703.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA26_RS07195 (MUA26_07175) 1472289..1473011 - 723 WP_262603514.1 amino acid ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(131-195)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 6189.45 Da        Isoelectric Point: 3.8145

>T240052 WP_262603510.1 NZ_CP094717:c1468635-1468477 [Staphylococcus sp. IVB6246]
MNKQENEHGMVDSFDEVVELGKEMEQISEENDEEKYEQSHEEAVRSDRETDE

Download         Length: 159 bp

>T240052 NZ_LS483484:c1631068-1630823 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22037.03 Da        Isoelectric Point: 5.6098

>AT240052 WP_262603511.1 NZ_CP094717:c1469253-1468654 [Staphylococcus sp. IVB6246]
MAMNFKIFKDQNTAATFVADILRKQFSNNPTTIAGIHLKNDDAPVNGALQINVENNPVDFSQIHILDYDKNDAYFKALGV
PEKQIHEIPEDEKVEAFIKHHAKTKENKGKLTLQVVTIDTDGSIGIPMNDAVLTAREIVLVLTGAEKAEVVRKLYEENGS
TTFVPSSLKSHRMVNVVLDEAAAQGLPEDVRAYFSARFA

Download         Length: 600 bp

>AT240052 NZ_LS483484:1630489-1630854 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References