Detailed information of TA system TA240051

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1923662..1924123
• Replicon: chromosome
• Accession: NZ_CP094715
• Organism: Staphylococcus pasteuri strain IVB6198

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: A0A653ZJR3
• Locus tag: MUA61_RS09365
• Protein ID: WP_029055618.1
• Coordinates: 1923938..1924123 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: A0A653ZJ41
• Locus tag: MUA61_RS09360
• Protein ID: WP_072291797.1
• Coordinates: 1923662..1923919 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA61_RS09320 (MUA61_09310)	1918870..1919193	+	324	WP_017637481.1	thioredoxin family protein	-
MUA61_RS09325 (MUA61_09315)	1919302..1919841	-	540	WP_017637482.1	nitroreductase	-
MUA61_RS09330 (MUA61_09320)	1919920..1920636	-	717	WP_070452386.1	type I 3-dehydroquinate dehydratase	-
MUA61_RS09335 (MUA61_09325)	1920820..1921242	+	423	WP_017637484.1	organic hydroperoxide resistance protein	-
MUA61_RS09340 (MUA61_09330)	1921526..1922017	+	492	WP_017637485.1	GNAT family N-acetyltransferase	-
MUA61_RS09345 (MUA61_09335)	1922176..1922763	-	588	WP_017637486.1	histidine phosphatase family protein	-
MUA61_RS09350 (MUA61_09340)	1922935..1923159	+	225	WP_017637487.1	hypothetical protein	-
MUA61_RS09355 (MUA61_09345)	1923160..1923363	-	204	WP_029055617.1	sterile alpha motif-like domain-containing protein	-
MUA61_RS09360 (MUA61_09350)	1923662..1923919	+	258	WP_072291797.1	hypothetical protein	Antitoxin
MUA61_RS09365 (MUA61_09355)	1923938..1924123	+	186	WP_029055618.1	hypothetical protein	Toxin
MUA61_RS09370 (MUA61_09360)	1924265..1924801	+	537	WP_252458137.1	lipoprotein N-acylation protein LnsA	-
MUA61_RS09375 (MUA61_09365)	1924861..1925094	-	234	WP_070452389.1	hypothetical protein	-
MUA61_RS09380 (MUA61_09370)	1925332..1926080	+	749	Protein_1812	poly-gamma-glutamate hydrolase family protein	-
MUA61_RS09385 (MUA61_09375)	1926169..1926453	+	285	WP_070452395.1	hypothetical protein	-
MUA61_RS09390 (MUA61_09380)	1926530..1926745	+	216	WP_124760755.1	hypothetical protein	-
MUA61_RS09395 (MUA61_09385)	1927229..1927462	+	234	WP_017637830.1	hypothetical protein	-
MUA61_RS09400 (MUA61_09390)	1927682..1927915	+	234	WP_029056555.1	hypothetical protein	-
MUA61_RS09405 (MUA61_09395)	1928134..1928334	-	201	WP_002450876.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7023.71 Da
• Isoelectric Point: 10.1605

>T240051 WP_029055618.1 NZ_CP094715:1923938-1924123 [Staphylococcus pasteuri]
MSLHFTILFWLSIIFLIAGTIVLVTMLKTKKESKKESYLGFTIVFFIFGLAMLIYTLIFGL

Nucleotide

• Length: 186 bp

>T240051 NZ_LS483484:1046279-1046386 [Staphylococcus aureus]
GTGATATCTATTGCAAACGCATTACATTTAATGTTAAGTTTCGGTATGTTTATCGTCACTTTCATTGGTGTAGTAGTCGC
AATAATTAATTTAAACAATAAAAAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9929.12 Da
• Isoelectric Point: 4.1911

>AT240051 WP_072291797.1 NZ_CP094715:1923662-1923919 [Staphylococcus pasteuri]
MKLYFLHVINILLTILFVIFNIVITNNTNLDDTLWLVPGLIVCGLIIIISLFIAISNKDLLSEILFFINIILTLYYIYPI
FYDFL

Nucleotide

• Length: 258 bp

>AT240051 NZ_LS483484:c1046495-1046381 [Staphylococcus aureus]
TAAAAAGACGACATGCAGGAACATGTCGCCTAATGAGCCCGTTAAAAAGACGGTGACTAAATGAGATTTTCTTTAACCAT
CATTCGTTGTCAAAGTTTTGAAATGATGGTTATTT

Structures

Toxin

• AlphaFold DB: A0A653ZJR3

Antitoxin

• AlphaFold DB: A0A653ZJ41