Detailed information of TA system TA024005

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta-couple_hipB
• Location: 1044439..1045691
• Replicon: chromosome
• Accession: NC_012926
• Organism: Streptococcus suis BM407

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: A0A0Z9JWN4
• Locus tag: SSUBM407_RS05130
• Protein ID: WP_011922437.1
• Coordinates: 1044915..1045691 (+)
• Length: 259 a.a.

Antitoxin (Protein)

• Gene name: sezA
• Uniprot ID: -
• Locus tag: SSUBM407_RS05125
• Protein ID: WP_012775115.1
• Coordinates: 1044439..1044915 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SSUBM407_RS05090	1039670..1039894	-	225	WP_000205227.1	helix-turn-helix transcriptional regulator	-
SSUBM407_RS05095	1040037..1040117	-	81	Protein_961	site-specific recombinase	-
SSUBM407_RS05100	1041609..1042247	+	639	WP_011922443.1	hypothetical protein	-
SSUBM407_RS05105	1042286..1043362	+	1077	WP_011922442.1	toprim domain-containing protein	-
SSUBM407_RS05110	1043416..1043643	+	228	WP_011922441.1	hypothetical protein	-
SSUBM407_RS05115	1043640..1044029	+	390	WP_011922440.1	methyl-accepting chemotaxis protein	-
SSUBM407_RS05120	1044079..1044369	+	291	WP_024379089.1	hypothetical protein	-
SSUBM407_RS05125	1044439..1044915	+	477	WP_012775115.1	helix-turn-helix domain-containing protein	Antitoxin
SSUBM407_RS05130	1044915..1045691	+	777	WP_011922437.1	zeta toxin family protein	Toxin
SSUBM407_RS05135	1045688..1047775	+	2088	WP_011922436.1	AAA family ATPase	-
SSUBM407_RS05140	1047762..1049579	+	1818	WP_012775114.1	ATP-dependent helicase	-
SSUBM407_RS05145	1049674..1049991	-	318	Protein_971	ATP-binding protein	-
SSUBM407_RS05150	1050335..1050649	+	315	WP_012775608.1	YdcP family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(O) / ant(6)-Ia / tet(M) / tet(L)	-	1032547..1125755	93208

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (28-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 259 a.a.
• Molecular weight: 29171.98 Da
• Isoelectric Point: 5.2489

>T24005 WP_011922437.1 NC_012926:1044915-1045691 [Streptococcus suis BM407]
MRLEEFSEAAFQKALQRTIRALIRGKTIPEQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLASKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLSELEREQLFDQIQIYQRDRTCIYDSEIDEGSAVEVLQECLFGQWSKVEEEML
KAGQERLGELVSANGEKK

Nucleotide

• Length: 777 bp

>T24005 NC_012926:1044915-1045691 [Streptococcus suis BM407]
ATGAGGTTGGAAGAATTTAGTGAGGCTGCATTTCAGAAGGCCTTACAGCGAACCATTCGGGCTTTAATCCGAGGCAAAAC
AATTCCAGAACAACCGAAAGCTATCTTACTTGGAGGACAAAGCGGAGCCGGTAAGACAACGATTCATCGGATTAAGCAAA
AGGAATTTCAAGGCAATATCATTATCATCGATGGTGACAGCTACCGTTCTCAACATCCCAATTACTTAGCACTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAACATCTGGTTGATGAACTTAGTAC
ACAAGGTTATCATTTGTTAATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGCTTCGA
AAGGATACCAAGTTTCCTTAGCTGTGATTGGTACCAAACCAGAATTGTCCTATCTCAGCACCTTGATTCGTTACGAAGAA
CTTTATGCTATCGATCCTAATCAGGCTAGAGCAACACCAAAAGAACACCATGATGGGATTGTTGAGAACTTGGTTGATAA
CCTAAGCGAGTTAGAAAGAGAGCAACTCTTTGACCAAATTCAAATTTATCAAAGAGATAGAACTTGTATCTATGATTCTG
AAATTGATGAGGGATCCGCGGTAGAAGTGCTACAAGAATGCCTCTTTGGGCAATGGAGTAAAGTCGAGGAAGAGATGTTG
AAGGCCGGACAGGAACGGTTGGGGGAATTAGTCTCAGCTAATGGAGAGAAGAAATGA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18282.69 Da
• Isoelectric Point: 4.4750

>AT24005 WP_012775115.1 NC_012926:1044439-1044915 [Streptococcus suis BM407]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Nucleotide

• Length: 477 bp

>AT24005 NC_012926:1044439-1044915 [Streptococcus suis BM407]
ATGATCGGAGACAATATAAAATCACTACGCCGAACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTCGGGATTTC
ACGCAATAGTCTGAGTCGCTACGAAAATGGAACCAGCACTGTTTCAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGTTAACTCCTGTCGAAGATTACCATCTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATCGATATCAAGATAGTCAGGATATTGCTTTTGATGATGA
ATCCAACCCTTGGATTCTCATGAGTGATGATTTGGCTGAATTGATCAATACGAAAATTTACCTTGTCGATACTTTCGATG
AAATTGAGCGTTACAATGGCTATTTAGACGGTATCGAGCGGATGTTGGACATGGTGCATCATCGGGTGGTGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Z9JWN4