Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 820157..820686 Replicon chromosome
Accession NZ_CP094715
Organism Staphylococcus pasteuri strain IVB6198

Toxin (Protein)


Gene name mazF Uniprot ID A0A654BHV4
Locus tag MUA61_RS03950 Protein ID WP_017637331.1
Coordinates 820324..820686 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4PXF4
Locus tag MUA61_RS03945 Protein ID WP_002451626.1
Coordinates 820157..820327 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA61_RS03920 (MUA61_03920) 815974..816447 + 474 WP_029056193.1 PH domain-containing protein -
MUA61_RS03925 (MUA61_03925) 816440..817972 + 1533 WP_262552836.1 PH domain-containing protein -
MUA61_RS03930 (MUA61_03930) 817959..818453 + 495 WP_070452937.1 PH domain-containing protein -
MUA61_RS03935 (MUA61_03935) 818491..818868 + 378 WP_046466914.1 holo-ACP synthase -
MUA61_RS03940 (MUA61_03940) 818917..820065 + 1149 WP_119622766.1 alanine racemase -
MUA61_RS03945 (MUA61_03945) 820157..820327 + 171 WP_002451626.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA61_RS03950 (MUA61_03950) 820324..820686 + 363 WP_017637331.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA61_RS03955 (MUA61_03955) 821010..822011 + 1002 WP_017637330.1 PP2C family protein-serine/threonine phosphatase -
MUA61_RS03960 (MUA61_03960) 822106..822432 + 327 WP_029056199.1 anti-sigma factor antagonist -
MUA61_RS03965 (MUA61_03965) 822434..822913 + 480 WP_017637328.1 anti-sigma B factor RsbW -
MUA61_RS03970 (MUA61_03970) 822888..823658 + 771 WP_029056200.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13586.75 Da        Isoelectric Point: 9.9783

>T240046 WP_017637331.1 NZ_CP094715:820324-820686 [Staphylococcus pasteuri]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSENKMKEVDYALDISLGLHNFNHPKT

Download         Length: 363 bp

>T240046 NZ_LS483480:c1614350-1614045 [Haemophilus influenzae]
ATGTTTAATTTAAAGCGTGAGCATTTTAGAGATGATTATCTTTATAGGTTTTATCAATATGGTGATACTCATAGTAAGAT
TCCTTCTAATTTGTATAAAGTATTGGCAAGAAAATTAGATATGATAAGTGCCTCAGAAAATATCAACGATTTACGTTCTC
CACCAGCTAACCATTTGGAGTTGCTTGAGCCAAAAGAAAATAAAATTTATTCCATTCGAGTGAATAAACAATATCGTTTA
ATTTTTAAATATGAAAATAACGAAGTAAATAATTTATATTTAGATCCACATTCTTATAATTTGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6300.94 Da        Isoelectric Point: 3.8309

>AT240046 WP_002451626.1 NZ_CP094715:820157-820327 [Staphylococcus pasteuri]
MLSFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNAKNE

Download         Length: 171 bp

>AT240046 NZ_LS483480:c1614034-1613711 [Haemophilus influenzae]
ATGATGACGAGAAAACCCACCTCTGTTGGTGAAATTCTACAAGAAGAGTTTTTAGAACCTTTAAGTCTTAAAATTAGTGA
TTTAGCTCAAATTTTAGATGTACATCGTAATACGGCAAGCAATATTGTTAATAATAGTTCACGAATTACGCTAGAAATGG
CAGTTAAACTTGCTAAAGTATTTGATACTACGCCTGAGTTTTGGCTTAATCTGCAAACACGTATTGATTTATGGGACCTT
GAACACAATAAACGTTTTCAACAAAGTCTTGCAAATGTTAAGCCCGCTCTACATCGGCATGATACTTCTACATTTGCAAT
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A654BHV4

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4PXF4

References