Detailed information of TA system TA240045

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 809020..809530
• Replicon: chromosome
• Accession: NZ_CP094715
• Organism: Staphylococcus pasteuri strain IVB6198

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: MUA61_RS03890
• Protein ID: WP_070452945.1
• Coordinates: 809324..809530 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A654BGA3
• Locus tag: MUA61_RS03885
• Protein ID: WP_017636753.1
• Coordinates: 809020..809313 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA61_RS03860 (MUA61_03860)	804172..804963	+	792	WP_070452950.1	hydroxyethylthiazole kinase	-
MUA61_RS03865 (MUA61_03865)	804964..805605	+	642	WP_017636757.1	thiamine phosphate synthase	-
MUA61_RS03870 (MUA61_03870)	805694..806563	+	870	WP_017636756.1	membrane protein insertase YidC	-
MUA61_RS03875 (MUA61_03875)	806603..807247	-	645	WP_017636755.1	HD domain-containing protein	-
MUA61_RS03880 (MUA61_03880)	807347..808831	-	1485	WP_070452947.1	cardiolipin synthase	-
MUA61_RS03885 (MUA61_03885)	809020..809313	+	294	WP_017636753.1	copper-sensing transcriptional repressor CsoR	Antitoxin
MUA61_RS03890 (MUA61_03890)	809324..809530	+	207	WP_070452945.1	heavy metal-associated domain-containing protein	Toxin
MUA61_RS03895 (MUA61_03895)	809675..809794	+	120	WP_262553149.1	Lmo0850 family protein	-
MUA61_RS03900 (MUA61_03900)	809929..811119	-	1191	WP_046466910.1	FtsW/RodA/SpoVE family cell cycle protein	-
MUA61_RS03905 (MUA61_03905)	811491..812561	+	1071	WP_029056190.1	D-alanine--D-alanine ligase	-
MUA61_RS03910 (MUA61_03910)	812577..813938	+	1362	WP_070452941.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (18-66)

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7642.63 Da
• Isoelectric Point: 4.4368

>T240045 WP_070452945.1 NZ_CP094715:809324-809530 [Staphylococcus pasteuri]
VQQKIVYTSGIKTTEQGNKMETILKEMIGVYDANVDLSNGHISVEFETPANLNSIEKEIYDSGFKVLY

Nucleotide

• Length: 207 bp

>T240045 NZ_LS483480:c1403703-1403404 [Haemophilus influenzae]
ATGACAATCCAAATCAAAACCACTCTGACATTTGATTCTTGGTTAAGCAAACTAAAAAACTTGCGTGCCAAAGCGAAAAT
AAACGCACGAATTAAACGCTTACAGTTCGGCAACTTTGGTGATATCAAAAGTGTGAATGATGGGATTTTTGAATTACGGA
TTGATGAAGGTCAAGGTTATCGAATTTATCTTAAAAACCAGAATGGCGTATTAGTGATTTTACTTTGTGGCGGAGATAAA
TCCACACAAGAGAAAGATATTAAACAAGCAAAACTTCTCGCACAGGAGCTAGGATTATGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11231.74 Da
• Isoelectric Point: 6.3270

>AT240045 WP_017636753.1 NZ_CP094715:809020-809313 [Staphylococcus pasteuri]
VTEQDHAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCITEKVNNGHQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT240045 NZ_LS483480:c1403407-1403114 [Haemophilus influenzae]
ATGACTGAACAATTAAAAGACTTTGATGTGGCAGAACACCTCATTTCTGAAGAAGAAATTCAACTTTACCTTAATGAAAT
TCTACAAGAAGATAATATTGAGCTTATTTTATCCTCCCTTGGCGACATAGCTCGTGCGCGTAACATGAGCCAAATCGCAC
GTGATGCAGGGATAAGCCGAGAAGGTCTTTATAAAGCCTTATCTGGCACGGGCAATCCTACTTTTGCTACTGTAATGAAA
GTAATGAAAGCCTTAAATTTACAGTTCCAAGTTCAACAATCTCGATTCGCCTAA

Structures

Antitoxin

• AlphaFold DB: A0A654BGA3