Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF-doc
Location 34139..34722 Replicon chromosome
Accession NZ_CP094715
Organism Staphylococcus pasteuri strain IVB6198

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag MUA61_RS00140 Protein ID WP_070451747.1
Coordinates 34139..34477 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag MUA61_RS00145 Protein ID WP_262553122.1
Coordinates 34474..34722 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA61_RS00125 (MUA61_00125) 30079..30558 + 480 WP_002466394.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
MUA61_RS00130 (MUA61_00130) 30829..32133 - 1305 WP_070451749.1 poly-gamma-glutamate hydrolase family protein -
MUA61_RS00135 (MUA61_00135) 32494..33993 + 1500 WP_154835527.1 NAD-dependent epimerase/dehydratase family protein -
MUA61_RS00140 (MUA61_00140) 34139..34477 - 339 WP_070451747.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA61_RS00145 (MUA61_00145) 34474..34722 - 249 WP_262553122.1 AbrB family transcriptional regulator Antitoxin
MUA61_RS00150 (MUA61_00150) 35013..35369 - 357 WP_262552033.1 hypothetical protein -
MUA61_RS00155 (MUA61_00155) 35377..35949 - 573 WP_262552036.1 ABC transporter substrate-binding protein -
MUA61_RS00160 (MUA61_00160) 36026..36730 + 705 WP_070451741.1 alpha/beta hydrolase-fold protein -
MUA61_RS00165 (MUA61_00165) 36916..37074 + 159 WP_017638051.1 hypothetical protein -
MUA61_RS00170 (MUA61_00170) 37075..37653 + 579 WP_051522845.1 Fic family protein -
MUA61_RS00175 (MUA61_00175) 37939..38742 + 804 WP_070451739.1 Cof-type HAD-IIB family hydrolase -
MUA61_RS00180 (MUA61_00180) 39045..39542 + 498 WP_070451737.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13132.24 Da        Isoelectric Point: 8.8818

>T240044 WP_070451747.1 NZ_CP094715:c34477-34139 [Staphylococcus pasteuri]
MSIKQFDILYIDLDPTRGREKQKIRPCLVINNQMSIEGTDFVWVLPITNREVRFPTDIEVKTKKGLVTGVIDTIQIRSLD
LNVRYHNYRDELQDNLKKDVLQAVQTYLKPTL

Download         Length: 339 bp

>T240044 NZ_LS483480:c1403407-1403114 [Haemophilus influenzae]
ATGACTGAACAATTAAAAGACTTTGATGTGGCAGAACACCTCATTTCTGAAGAAGAAATTCAACTTTACCTTAATGAAAT
TCTACAAGAAGATAATATTGAGCTTATTTTATCCTCCCTTGGCGACATAGCTCGTGCGCGTAACATGAGCCAAATCGCAC
GTGATGCAGGGATAAGCCGAGAAGGTCTTTATAAAGCCTTATCTGGCACGGGCAATCCTACTTTTGCTACTGTAATGAAA
GTAATGAAAGCCTTAAATTTACAGTTCCAAGTTCAACAATCTCGATTCGCCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9339.53 Da        Isoelectric Point: 5.1745

>AT240044 WP_262553122.1 NZ_CP094715:c34722-34474 [Staphylococcus pasteuri]
MNKTSERIFKNGNSKAMSLSKQTIQLANFDVGDKVEVQEMNGGLFIKKKEESIEDRITNFFKNGGKYTETEIDFVESVGR
EI

Download         Length: 249 bp

>AT240044 NZ_LS483480:c1403703-1403404 [Haemophilus influenzae]
ATGACAATCCAAATCAAAACCACTCTGACATTTGATTCTTGGTTAAGCAAACTAAAAAACTTGCGTGCCAAAGCGAAAAT
AAACGCACGAATTAAACGCTTACAGTTCGGCAACTTTGGTGATATCAAAAGTGTGAATGATGGGATTTTTGAATTACGGA
TTGATGAAGGTCAAGGTTATCGAATTTATCTTAAAAACCAGAATGGCGTATTAGTGATTTTACTTTGTGGCGGAGATAAA
TCCACACAAGAGAAAGATATTAAACAAGCAAAACTTCTCGCACAGGAGCTAGGATTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References